Clinical Trials Logo

Atrophy clinical trials

View clinical trials related to Atrophy.

Filter by:

NCT ID: NCT03845582 Active, not recruiting - Clinical trials for Age Related Macular Degeneration

Phase 3 Study of ALK-001 in Geographic Atrophy

SAGA
Start date: May 7, 2019
Phase: Phase 3
Study type: Interventional

This is a double-masked, multicenter, randomized, placebo-controlled clinical trial, evaluating the efficacy and safety of ALK-001 in participants with Geographic Atrophy (GA) secondary to age-related macular degeneration (AMD). Up to 200 participants will receive ALK-001 while up to 100 participants will receive a placebo.

NCT ID: NCT03815825 Active, not recruiting - Clinical trials for Macular Degeneration

GOLDEN STUDY: A Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)

Start date: March 4, 2019
Phase: Phase 2
Study type: Interventional

Evaluate the effect of IONIS-FB-LRx on the rate of change of the area of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) measured by fundus autofluorescence (FAF).

NCT ID: NCT03814629 Active, not recruiting - Clinical trials for Chronic Atrophic Gastritis With Hyperplasia (Diagnosis)

Clinical Study of Weifuchun Treatment on Precancerous Lesions of Gastric Cancer

Start date: August 1, 2015
Phase: Early Phase 1
Study type: Interventional

Research purpose To elucidate the effect mechanism and clinical effective of weifuchun in the prevention and treatment of chronic atrophic gastritis and precancerous lesions of gastric cancer. From genes related to cell differentiation, proliferation, apoptosis, tumor invasion and metastasis, genes related to immune inflammation and immune escape and other possible aspects to elucidate the effective and mechanism of weifuchun's treatment on chronic atrophic gastritis, reversing precancerous lesions of gastric cancer.

NCT ID: NCT03808519 Active, not recruiting - Sarcopenia Clinical Trials

n3 PUFA and Muscle-disuse Atrophy in Older Women

Start date: February 18, 2019
Phase: N/A
Study type: Interventional

This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in older women undergoing 1 week of unilateral limb immobilization. Assessments in skeletal muscle strength and skeletal muscle volume will also me made before, after and in recovery from immobilization.

NCT ID: NCT03779334 Active, not recruiting - Clinical trials for Muscular Atrophy, Spinal

A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy

Rainbowfish
Start date: August 7, 2019
Phase: Phase 2
Study type: Interventional

A global study of oral risdiplam in pre-symptomatic participants with spinal muscular atrophy (SMA).

NCT ID: NCT03754205 Active, not recruiting - Vaginal Atrophy Clinical Trials

Vaginal CO2 Laser and the Genitourinary Syndrome of Menopause

Start date: January 18, 2018
Phase: N/A
Study type: Interventional

This study evaluates the clinical, histopathological, cytological and microbiological efficacy of Microablative Fractional CO2 laser intravaginally administered in postmenopausal women with Genitourinary Syndrome of Menopause. Half participants will receive active CO2 laser therapy, while the other half will receive placebo CO2 laser therapy.

NCT ID: NCT03706118 Active, not recruiting - Multiple Sclerosis Clinical Trials

Physiologic Volume and Atrophy of Brain and Spinal Cord Measured by Magnetic Resonance Imaging

Start date: March 15, 2018
Phase: N/A
Study type: Interventional

Spinal cord (SC) involvement is prevalent in multiple sclerosis (MS) and contributes importantly to disease progression. To be able reliably evaluate spinal cord volume and its changes in MS patients we need to understand variability of these parameters in sex and age matched healthy controls (HC). To date, no generally available data about these parameters in HC are available. The objective of this study is to investigate age and sex matched HC by MRI to get the basic set of the data representing both cross sectional values and its longitudinal changes. The present study will also investigate different strategies how to normalize the absolute spinal cord and brain volume data, what is a relationship between spinal cord volume and brain volume and what is the best protocol to be used in a routine clinical practice.

NCT ID: NCT03540316 Active, not recruiting - Clinical trials for Atrophy of Edentulous Mandibular Alveolar Ridge

Treatment Outcome of Short Implant Assisted Mandibular Overdenture

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the use of short dental implants to support mandibular overdenture together with the use of laser therapy for treatment of patients with atrophic ridges. All participants will receive laser therapy; half of participants will receive two short implants and the other half will receive four short implants.

NCT ID: NCT03496038 Active, not recruiting - Clinical trials for Edentulous; Alveolar Process, Atrophy

Transcrestal Lateral Sinus Floor Elevation in Implant Therapy

Start date: March 19, 2018
Phase: N/A
Study type: Interventional

This is a non-inferiority study to evaluate whether L-PRF achieves similar or perhaps better results in bone gain, compared with "the golden standard" DBBM, after trans-crestal sinus floor elevation.

NCT ID: NCT03495700 Active, not recruiting - Clinical trials for Edentulous; Alveolar Process, Atrophy

Lateral Sinus Floor Elevation in Implant Therapy.

Start date: March 19, 2018
Phase: N/A
Study type: Interventional

The L-PRF block is a combination of bone substitute with L-PRF. The use of a L-PRF block in bone augmentation therapies could enhance and improve bone regeneration. The primary objective of this study is to evaluate if the use of autologous leukocytes and platelet rich fibrin accelerate and promotes bone regeneration in the sinus in comparison with the standard sinus lift procedure procedure.