Atrial Fibrillation Clinical Trial
— LIBREXIA-AFOfficial title:
A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel Group, Active-Controlled Study to Evaluate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, Versus Apixaban in Participants With Atrial Fibrillation
The purpose of this study is to evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-central nervous system (CNS) systemic embolism.
| Status | Recruiting |
| Enrollment | 15500 |
| Est. completion date | May 5, 2027 |
| Est. primary completion date | March 5, 2027 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Minimum age of 18 years - Medically stable and appropriate for chronic antithrombotic treatment - Atrial fibrillation eligible to receive anticoagulation - Participant must satisfy one or both of the following categories of risk factors (a or b): a) one or more of the following risk factors: i) age greater than or equal to 75 years, ii) history of any type of stroke including symptomatic stroke of any kind. b) two or more of the following risk factors: i) age between 65 and 74 years, ii) hypertension, iii) diabetes mellitus, iv) atherosclerotic vascular disease, v) heart failure Exclusion Criteria: - Hemodynamically significant valve disease or those with valve disease that will potentially require surgical valve replacement during the study - Any condition other than AF that requires chronic anticoagulation |
| Country | Name | City | State |
|---|---|---|---|
| Argentina | Instituto de Investigaciones Clinicas Bahia Blanca | Bahia Blanca | |
| Argentina | CEMEDIC | Buenos Aires | |
| Argentina | Sanatorio Finochietto | Buenos Aires | |
| Argentina | CINME Centro de Investigaciones Metabolicas | Caba | |
| Argentina | Clínica y Maternidad Suizo Argentina | Capital Federal | |
| Argentina | Consultorio Dr. Litvak Bruno | Ciudad Autonoma Buenos Aires | |
| Argentina | Consultorios Asociados de Endocrinología e Investigación Clínica Aplicada | Ciudad Autonoma Buenos Aires | |
| Argentina | Fundacion Favaloro | Ciudad Autonoma Buenos Aires | |
| Argentina | Glenny Corp. S.A. - Bioclinica Argentina | Ciudad Autonoma Buenos Aires | |
| Argentina | Instituto Cardiovascular de Buenos Aires | Ciudad Autonoma Buenos Aires | |
| Argentina | CEDIC Centro de Investigaciones Clinicas | Ciudad Autonoma de Buenos Aires | |
| Argentina | CIPREC | Ciudad Autonoma de Buenos Aires | |
| Argentina | Clinica Adventista Belgrano | Ciudad De Buenos Aires | |
| Argentina | Fundacion Scherbovsky | Ciudad de Mendoza | |
| Argentina | Clínica Colombo | Cordoba | |
| Argentina | Hospital San Roque | Cordoba | |
| Argentina | Sanatorio Allende | Cordoba | |
| Argentina | Clinica Coronel Suarez | Coronel Suarez | |
| Argentina | CIPADI | Godoy Cruz | |
| Argentina | Centro Medico Lebensohn | Junin | |
| Argentina | Centro de Investigaciones Medicas Mar Del Plata | Mar del Plata | |
| Argentina | Instituto de Investigaciones Clinicas Mar del Plata | Mar Del Plata, Buenos Aires | |
| Argentina | Instituto de Investigaciones Clinicas de Rosario | Rosario | |
| Argentina | Sanatorio de la Mujer | Rosario | |
| Argentina | Sanatorio Parque | Rosario | |
| Argentina | Investigaciones Clinicas Cuyo | San Juan | |
| Argentina | Investigaciones Clinicas Tucuman | San Miguel de Tucuman | |
| Argentina | Instituto de Investigaciones Clinicas San Nicolas | San Nicolas | |
| Argentina | Centro de Investigaciones Clinicas del Litoral | Santa Fe | |
| Argentina | Sanatorio San Martin | Venado Tuerto | |
| Australia | Flinders Medical Centre | Adelaide | |
| Australia | Advara HeartCare Wesley | Brisbane | |
| Australia | Concord Repatriation General Hospital | Concord | |
| Australia | Peninsula Heart Center | Frankston | |
| Australia | Royal Brisbane and Women's Hospital | Herston | |
| Australia | GenesisCare Joondalup-Shenton House | Joondalup | |
| Australia | Novatrials | Kotara | |
| Australia | GenesisCare | Leabrook | |
| Australia | Core Research Group | Milton | |
| Australia | Brisbane Health Connect | Tarragindi | |
| Belgium | Algemeen Stedelijk Ziekenhuis | Aalst | |
| Belgium | ZNA Middelheim | Antwerpen | |
| Belgium | CSL Arlon | Arlon | |
| Belgium | C.H.U. Brugmann | Bruxelles | |
| Belgium | CUB Hôpital Erasme | Bruxelles | |
| Belgium | AZ Sint-Blasius | Dendermonde | |
| Belgium | UZA | Edegem | |
| Belgium | Jessa Ziekenhuis - Campus St.-Ursula | Herk-de-Stad | |
| Belgium | Chu Tivoli | La Louvière | |
| Belgium | UZ Leuven | Leuven | |
| Belgium | Az Sint-Maarten | Mechelen | |
| Belgium | Heilig Hart Ziekenhuis Lier | Mol | |
| Belgium | AZ Delta VZW | Roeselare | |
| Belgium | AZ Turnhout | Turnhout | |
| Brazil | Cardresearch - Cardiologia Assistencial | Belo Horizonte | |
| Brazil | Rede D or Sao Luiz S A Hospital do Coracao do Brasil | Brasilia | |
| Brazil | Sociedade Hospitalar Angelina Caron | Campina Grande Do Sul | |
| Brazil | C.E.C.-Centro Especializado em Cardiologia Ltda.- Loema Medicina e Bem Estar | Campinas | |
| Brazil | Instituto de Pesquisa Clinica de Campinas | Campinas | |
| Brazil | Instituto do Coracao de Marília | Marilia | |
| Brazil | Irmandade da Santa Casa de Misericórdia de Marília | Marilia | |
| Brazil | Hospital Alemao Oswaldo Cruz | Sao Paulo | |
| Brazil | Hospital Das Clinicas Da Faculdade De Medicina Da USP | Sao Paulo | |
| Brazil | Instituto Dante Pazzanese de Cardiologia | Sao Paulo | |
| Brazil | CEDOES | Vitória | |
| Bulgaria | MHAT Puls | Blagoevgrad | |
| Bulgaria | MC 4Life Ltd | Burgas | |
| Bulgaria | Medical Center Diamedical | Dimitrovgrad | |
| Bulgaria | MHAT St. Ekaterina | Dimitrovgrad | |
| Bulgaria | Medical Centre Asklepii OOD | Dupnitsa | |
| Bulgaria | Multiprofile Hospital for Active Treatment Dr. Tota Venkova | Gabrovo | |
| Bulgaria | Multiprofile Hospital for Active Treatment - Haskovo | Haskovo | |
| Bulgaria | Medical center Rodopimed EOOD | Kardzhali | |
| Bulgaria | UMHAT 'Pulmed' OOD- MS 'Zdrave' - Pazardzhik | Pazardzhik | |
| Bulgaria | Medical Center Medconsult-Pleven | Pleven | |
| Bulgaria | UMHAT 'Dr. Georgi Stranski', EAD | Pleven | |
| Bulgaria | UMHAT 'Heart and Brain Center for Excellence' | Pleven | |
| Bulgaria | UMHAT 'Sv. Georgi' EAD | Plovdiv | |
| Bulgaria | MC Rusemed ltd | Ruse | |
| Bulgaria | Medical Center- Prolet Ltd | Ruse | |
| Bulgaria | Medical Center Unimed Eood | Sevlievo | |
| Bulgaria | Acibadem City Clinic Tokuda Hospital | Sofia | |
| Bulgaria | DCC Ascendent EAD | Sofia | |
| Bulgaria | DCC Convex EOOD | Sofia | |
| Bulgaria | Diagnostic Consultation Centre 'Alexandrovska' EOOD | Sofia | |
| Bulgaria | Individual Ambulatory of Cardiology | Sofia | |
| Bulgaria | Medical Center Hera EOOD | Sofia | |
| Bulgaria | Medical Centre Kalimat | Sofia | |
| Bulgaria | Meditsinski Centar - Izgrev Eood | Sofia | |
| Bulgaria | Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead | Sofia | |
| Bulgaria | Second Multiprofile Hospital for Active Treatment MHAT - Sofia AD | Sofia | |
| Bulgaria | UMHAT Prof. Dr. Aleksandar Chirkov | Sofia | |
| Bulgaria | University Multiprofile Hospital for Active Treatment - Tsaritsa Yoanna - ISUL, EAD | Sofia | |
| Bulgaria | Medical Center ZaraMed | Stara Zagora | |
| Bulgaria | UMHAT Prof. Dr. St. Kirkovich AD | Stara Zagora | |
| Bulgaria | DCC Chaika EOOD | Varna | |
| Bulgaria | Medical Center -Medika Plus | Veliko Tarnovo | |
| Bulgaria | MHAT Dr Stefan Cherkezov | Veliko Tarnovo | |
| Bulgaria | MHAT Sv. Panteleymon AD | Yambol | |
| Canada | Brampton Research Assoc | Brampton | Ontario |
| Canada | The Governers of the University of Calgary | Calgery | Alberta |
| Canada | Dr. Saul Vizel Cardiac Research Office | Cambridge | Ontario |
| Canada | ViaCar Recherche Clinique Inc | Greenfield Park | Quebec |
| Canada | Queen Elizabeth II - Health Sciences Centre | Halifax | Nova Scotia |
| Canada | One Heart Care | Mississauga | Ontario |
| Canada | CHUM - Pavillon B | Montreal | Quebec |
| Canada | Fraser Clinical Trials Inc. | New Westminster | British Columbia |
| Canada | Dr. James Cha | Oshawa | Ontario |
| Canada | Kawartha Cardiology Clinical Trials | Peterborough | Ontario |
| Canada | Montreal Heart Institute | Quebec | |
| Canada | Surrey Memorial Hospital | Surrey | British Columbia |
| Canada | Victoria Cardiac Arrhythmia Trials Inc | Victoria | British Columbia |
| Canada | CPS Research | Waterloo | Ontario |
| Chile | Quantum Research | Puerto Varas | |
| Chile | BioMedica Research Group | Santiago | |
| Chile | CeCim - Centro de Estudios Clinicos e Investigacion Medica | Santiago | |
| Chile | Centro de Investigacion Clinica Universidad Catolica de Chile CICUC | Santiago | |
| Chile | Enroll Spa | Santiago | |
| Chile | SMOLAM | Santiago | |
| Chile | Sociedad Medica Cardiologica El Llano | Santiago | |
| Chile | Centro de Estudios Cardiologicos y de Medicina Interna | Temuco | |
| Chile | Centro de Investigacion Clinica del Sur | Temuco | |
| Chile | Centro de Estudios Clinicos V Region Ltda | Vina del Mar | |
| China | Chinese PLA General Hospital | Beijing | |
| China | Jilin Province Peoples Hospital | Changchun | |
| China | The First Hospital of Jilin University | Changchun | |
| China | The Third Xiangya Hospital of Central South University | Changsha | |
| China | Changzhou No 2 Peoples Hospital | Changzhou City | |
| China | Sichuan Provincial Peoples Hospital | Chengdu | |
| China | West China Hospital Sichuan University | Chengdu | |
| China | Chongqing General Hospital | Chongqing | |
| China | Heilongjiang Daqing People's Hospital | Daqing | |
| China | Dongguan People s Hospital | Dongguan | |
| China | The First Affiliated Hospital of Fujian Medical University | Fuzhou | |
| China | Jiangxi Ganzhou Peoples Hospital | Ganzhou | |
| China | Guangdong Provincial People's Hospital | Guangzhou | |
| China | The First Affiliated Hospital of Sun Yat-Sen University | Guangzhou | |
| China | The Third Affiliated Hospital Sun Yat sen University | Guangzhou | |
| China | ZhuJiang Hospital of Southern Medical University | Guangzhou | |
| China | GuiZhou Privicial Peoples Hospital | Guiyang | |
| China | The Affiliated Hospital of Guizhou Medical University | Guiyang | |
| China | Affiliated Hospital of Hainan Medical University | Haikou | |
| China | Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine | Hangzhou | |
| China | The second hospital of Anhui medical university | Hefei | |
| China | Inner Mongolia People's Hospital | Huhehaote | |
| China | Jieyang Peoples Hospital | Jieyang | |
| China | Qilu Hospital of Shandong University | Jinan | |
| China | Shandong Jining No.1 People's Hospital | Jining | |
| China | Lanzhou University Second Hospital | Lanzhou | |
| China | Jiangxi Provincial Peoples Hospital | Nanchang | |
| China | The Second Affiliatde Hospital To Nanchang University | Nanchang | |
| China | Ningbo First Hospital | Ningbo | |
| China | Jinshan Hospital Fudan University | Shanghai | |
| China | Zhongshan Hospital Fudan University | Shanghai | |
| China | Shengjing Hospital Of China Medical University | Shenyang | |
| China | The Second Hospital of Hebei Medical University | Shijiazhuang | |
| China | The First Affiliated Hospital of Soochow University | Suzhou | |
| China | Shanxi Cardiovascular Hospital | Taiyuan | |
| China | Taizhou First Peoples Hospital | Taizhou | |
| China | TEDA International Cardiovascular Hospital | Tianjin | |
| China | The 2nd Hospital of Tianjin Medical University | Tianjin | |
| China | Tianjin 4th Center Hospital | Tianjin | |
| China | Tianjin Chest Hospital | Tianjin | |
| China | Tianjin Medical University General Hospital | Tianjin | |
| China | Tianjin People's Hospital | Tianjin | |
| China | The First Affiliated Hospital of Wenzhou Medical University | Wenzhou | |
| China | Wenzhou Peoples Hospital | Wenzhou | |
| China | The Central Hospital of Wuhan | Wuhan | |
| China | The Third Affiliated Hospital of Xinxiang Medical University | Xinxiang | |
| China | Northern Jiangsu Peoples Hospital | Yangzhou | |
| China | Yantai Yuhuangding Hospital | Yantai | |
| China | General Hospital of Ningxia Medical Hospital | Yinchuan | |
| China | Affiliated Hospital Of Guangdong Medical University | Zhanjiang | |
| China | The 7th Peoples Hospital of Zhengzhou | Zhengzhou | |
| China | Affiliated Hospital of Zunyi Medical University | Zunyi | |
| Croatia | General Hospital Dubrovnik | Dubrovnik | |
| Croatia | Opca bolnica Karlovac | Karlovac | |
| Croatia | Clinic for Cardiovascular Disease Magdalena | Krapinske Toplice | |
| Croatia | Special Hospital for medical rehabilitation | Krapinske Toplice | |
| Croatia | OB Varazdin | Varazdin | |
| Croatia | Poliklinika Solmed | Zagreb | |
| Croatia | Polyclinic Bonifarm | Zagreb | |
| Croatia | University Hospital Dubrava | Zagreb | |
| Czechia | HUMANITAS spol. s r.o. | Bilovec | |
| Czechia | Interni ordinace s.r.o | Brandys nad Labem | |
| Czechia | MEDICUS SERVICES s.r.o. | Brandýs nad Labem | |
| Czechia | Fakultni nemocnice u sv. Anny v Brne | Brno | |
| Czechia | Vojenska nemocnice Brno | Brno | |
| Czechia | EDUMED s.r.o. | Broumov | |
| Czechia | Nemocnice Ceske Budejovice a s | Ceske Budejovice | |
| Czechia | Ordinace pro choroby srdce s.r.o. | Chomutov | |
| Czechia | MUDr. Jan Hubac s.r.o. | Chrudim | |
| Czechia | Kardiologie KarMa s.r.o | Jablonec nad Nisou | |
| Czechia | Lunacor s.r.o. - Ambulance kardiologie Centrum pro choroby srdce a cev | Kromeriz | |
| Czechia | Kardio Interna s.r.o. | Litovel | |
| Czechia | Fakultni nemocnice Olomouc | Olomouc | |
| Czechia | MUDr. Zdenek Vomacka kardiologie a interna s.r.o. | Olomouc | |
| Czechia | PreventaMed, s.r.o. | Olomouc | |
| Czechia | Cerebrovaskularni poradna s.r.o. | Ostrava Poruba | |
| Czechia | Pardubicka krajska nemocnice a s | Pardubice | |
| Czechia | Fakultni nemocnice Plzen | Plzen | |
| Czechia | MUDr. Eva Zídkova | Prague | |
| Czechia | Ústrední vojenské nemocnice Praha | Praha | |
| Czechia | Nemocnice Na Frantisku | Praha 1 | |
| Czechia | Fakultni nemocnice Kralovske Vinohrady | Praha 10 | |
| Czechia | MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna | Praha 10 | |
| Czechia | Centrum klinickeho vyzkumu | Pribram | |
| Czechia | Nemocnice Slany, interni oddeleni | Slany | |
| Czechia | Interni ambulance | Trutnov | |
| Czechia | Interni ambulance Dr.Stanislav Zemek | Uherske Hradiste | |
| Czechia | Cardio Research s r o | Zlin | |
| Denmark | Aarhus University Hospital | Aarhus | |
| Denmark | Amager Hospital | Copenhagen S | |
| Denmark | Gentofte Herlev Hospital | Herlev | |
| Denmark | Herning Regional Hospital | Herning | |
| Denmark | Holbæk Sygehus | Holbæk | |
| Denmark | Hvidovre Hospital | Hvidovre | |
| Denmark | Køge Sygehus Region Sjaelland | Køge | |
| Denmark | Slagelse Sygehus | Slagelse | |
| Denmark | Odense University Hospital | Svendborg | |
| Estonia | Dr. Arvo Rosenthal LLC | Tallinn | |
| France | CHU Angers - Hôpital Hôtel Dieu | Angers Cedex 9 | |
| France | Centre Hospitalier de la Cote Basque | Bayonne Cedex | |
| France | Centre Hospitalier de Beziers | Beziers cedex | |
| France | GH est - Hôpital Cardiovasculaire et Pneumologie Louis Pradel | Bron cedex | |
| France | Centre Hospitalier Sud Francilien | Corbeil Essonnes cedex | |
| France | Hopital Henri Mondor | Creteil | |
| France | CHU de Limoges Hopital Dupuytren | Limoges cedex | |
| France | Clinique Du Pont De Chaume | Montauban | |
| France | Centre Hospitalier Universitaire - de Nice - Hopital Pasteur | Nice Cedex 1 | |
| France | Hôpital Bichat - Claude Bernard | Paris | |
| France | Hopital Broca | Paris | |
| France | Hopital Lariboisiere | Paris | |
| France | Hopital Saint Joseph | Paris | |
| France | Hopital Saint-Antoine | Paris Cedex 12 | |
| France | CHU Poitiers - Hopital la Miletrie | Poitiers | |
| France | Clinique Saint-Hilaire - Centre Frédéric Joliot | Rouen | |
| France | Polyclinique Vauban | Valenciennes | |
| Germany | Klinikum Altenburger Land GmbH | Altenburg | |
| Germany | Klinikum am Plattenwald | Bad Friedrichshall | |
| Germany | Kardiologische Praxis Dr. med. univ. Jungmair | Bad Homburg | |
| Germany | Dres. Haas Kirschner Wagner | Bamberg | |
| Germany | Augentagesklinik Spreebogen Berlin GbR | Berlin | |
| Germany | Charite Campus Benjamin Franklin | Berlin | |
| Germany | Vivantes Humboldt Klinikum | Berlin | |
| Germany | Vivantes Klinikum Am Urban, Abt. fur Kardiologie | Berlin | |
| Germany | Vivantes Klinikum Hellersdorf | Berlin | |
| Germany | Vivantes Klinikum Im Friedrichshain | Berlin | |
| Germany | Klinikum Bielefeld | Bielefeld | |
| Germany | GFO Kliniken Bonn, Betriebsstaette St. Marien | Bonn-Beuel | |
| Germany | Medizinisches Versorgungszentrum (MVZ) Dachau | Dachau | |
| Germany | Gemeinschaftspraxis | Deggingen | |
| Germany | Praxis-Dr. Frank Menzel | Dessau-Rosslau | |
| Germany | FAZ Dresden-Neustadt GbR | Dresden | |
| Germany | Hausärztlich-Kardiologisches MVZ Am Felsenkeller GmbH | Dresden | |
| Germany | Stadtisches Klinikum Dresden | Dresden | |
| Germany | ZKS Südbrandenburg GMBH | Elsterwerda | |
| Germany | Gemeinschaftspraxis Dres. Hagemann und Breiderhoff | Essen | |
| Germany | Medizentrum Essen Borbeck | Essen | |
| Germany | Studienzentrum | Essen | |
| Germany | ClinPhenomics GmbH Co KG Studienzentrum Frankfurt | Frankfurt | |
| Germany | Universitaetsklinikum Freiburg | Freiburg | |
| Germany | ClinPhenomics GmbH Co KG Studienzentrum Frankfurt | Hamburg | |
| Germany | Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer GmbH | Hamburg | |
| Germany | Praxis Dr. Cornelia Schiewe | Hamburg | |
| Germany | Universitaetsklinikum Schleswig-Holstein Campus Kiel | Kiel | |
| Germany | Klinikum Ludwigshafen | Ludwigshafen, Rp | |
| Germany | Katholisches Klinikum Mainz; Innere Medizin I- Kardiologie | Mainz | |
| Germany | Praxis Für Pneumologie Und Allergologie | Mannheim | |
| Germany | Marienhaus Klinikum | Neuwied | |
| Germany | GP Dr. Haggenmiller PD Dr. Michael Jeserich | Nuremberg | |
| Germany | Kardiologische Praxis Papenburg | Papenburg | |
| Germany | Praxisgemeinschaft Stuhr-Brinkum | Stuhr | |
| Germany | Kardiologische Praxis | Wermsdorf | |
| Germany | Stadtkrankenhaus Worms | Worms | |
| Greece | Uni General Hospital of Alexandroupolis | Alexandroupolis | |
| Hungary | Lausmed Egeszsegugyi es Szolg. Kft. | Baja | |
| Hungary | DRC Gyogyszervizsgalo Kozpont Kft | Balatonfured | |
| Hungary | Belgyogyaszati es Kardiologiai Maganrendelo | Bekescsaba | |
| Hungary | Belvaros-Lipotvaros Egeszsegugyi Szolgalat | Budapest | |
| Hungary | Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely | Budapest | |
| Hungary | Gottsegen György Országos Kardiológiai Intézet | Budapest | |
| Hungary | Med-Tima Kft | Budapest | |
| Hungary | Obudai Egeszsegugyi Centrum Kft | Budapest | |
| Hungary | Semmelweis Egyetem | Budapest | |
| Hungary | Semmelweis Egyetem Városmajori Szív- és Érgyógyászati Klinika | Budapest | |
| Hungary | Szt. Rokus Hosp | Budapest | |
| Hungary | Uno Medical Trials Ltd. | Budapest | |
| Hungary | Belinus Orvosi es Szamtech. Bt. | Debrecen | |
| Hungary | Debreceni Egyetem | Debrecen | |
| Hungary | Bugat Pal Korhaz | Gyongyos | |
| Hungary | BKS Research Kft | Hatvan | |
| Hungary | Csongrád Megyei Egészségügyi Ellátó Központ Hódmezovásárhely | Hodmezovasarhely | |
| Hungary | Somogy Megyei Kaposi Mor Oktato Korhaz | Kaposvar | |
| Hungary | Bacs-kiskun Megyei Korhaz | Kecskemet | |
| Hungary | IPR Hungary Kft | Miskolc | |
| Hungary | TaNaMed Kft. | Mosonmagyarovar | |
| Hungary | Borbanya Praxis Eu. Kft. | Nyiregyhaza | |
| Hungary | Dr. Nagy Laszlo Kardiologiai Maganrendeles | Oroshaza | |
| Hungary | Coromed-Smo Kft | Pecs | |
| Hungary | Szegedi Tudomanyegyetem | Szeged | |
| Hungary | Vita Verum Medical Egeszsegugyi Szolgaltato Bt | Szekesfehervar | |
| Hungary | Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointez | Szolnok | |
| Hungary | Obudai Egeszsegugyi Centrum Kft | Zalaegerszeg | |
| Hungary | Zala Megyei Szent Rafael Korhaz | Zalaegerszeg | |
| Israel | Haemek Medical Center | Afula | |
| Israel | Hillel Yaffe Medical Center | Hadera | |
| Israel | Bnai Zion Medical Center | Haifa | |
| Israel | Carmel Medical Center | Haifa | |
| Israel | Wolfson Medical Center | Holon | |
| Israel | Hadassah Medical Center | Jerusalem | |
| Israel | Meir Medical Center | Kfar-Sava | |
| Israel | Holy Family Hospital | Nazareth | |
| Israel | Rabin Medical Center | Petah Tikva | |
| Israel | Chaim Sheba Medical Center | Ramat Gan | |
| Israel | Kaplan Medical Center | Rechovot | |
| Israel | Assaf Harofeh Medical Center | Rishon Lezion | |
| Israel | Ziv Medical Center | Safed | |
| Israel | Hadassah University Hospita Ein Kerem | Yerushalayim | |
| Italy | Ospedale San Donato - ASL 8 Arezzo | Arezzo | |
| Italy | ASL Caserta_Presidio Ospedaliero San Giuseppe e Melorio_U.O.C. di Cardiologia | Aversa | |
| Italy | Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII) | Bergamo | |
| Italy | Cliniche Humanitas Gavazzeni | Bergamo | |
| Italy | Azienda Opedaliero-Universitaria Policlinico Sant'orsola Malpighi di Bologna | Bologna | |
| Italy | AORN Sant'anna e San Sebastiano | Caserta | |
| Italy | P.O. Vittorio Emanuele Azienda Ospedaliero Universitaria 'Policlinico Vittorio Emanuele' | Catania | |
| Italy | AO di Catanzaro Pugliese Ciaccio | Catanzaro | |
| Italy | Arcispedale S. Anna Ferrara | Ferrara | |
| Italy | Ospedale Manzoni | Lecco | |
| Italy | Fondazione Toscana Gabriele Monasterio CNR | Massa | |
| Italy | A O Ospedale Niguarda Ca Granda | Milano | |
| Italy | Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico | Milano | |
| Italy | Azienda Socio Sanitaria Territoriale di Monza Presidio San Gerardo | Monza | |
| Italy | Fondazione IRCCS Policlinico San Matteo | Pavia | |
| Italy | A. O.U. Pisana Ospedale di Cisanello | Pisa | |
| Italy | A.O. San Camillo Forlanini | Roma | |
| Italy | AOU Policlinico Umberto I | Roma | |
| Italy | Fondazione Policlinico Universitario A Gemelli IRCCS | Roma | |
| Italy | Ospedale Sandro Pertini di Roma Reparto Emodinamica | Roma | |
| Italy | Istituto Clinico Humanitas | Rozzano | |
| Italy | P.O. Ss. Annunziata | Sassari | |
| Italy | Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino | Torino | |
| Italy | Azienda Ospedaliero Universitaria Ospedali Riuniti | Torrette Di Ancona | |
| Japan | Kasugai Municipal Hospital | Aichi | |
| Japan | Toyota Memorial Hospital | Aichi | |
| Japan | Tokyo Medical and Dental University Hospital | Bunkyo Ku | |
| Japan | Chiba University Hospital | Chiba | |
| Japan | Funabashi Munitiple Medical Center | Chiba | |
| Japan | Saiseikai Futsukaichi Hospital | Chikushino-shi | |
| Japan | Kyushu University Hospital | Fukuoka | |
| Japan | Nakamura Cardiovascular Clinic | Fukuoka | |
| Japan | National Hospital Organization Kyushu Medical Center | Fukuoka | |
| Japan | Steel Memorial Yawata Hospital | Fukuoka | |
| Japan | Tokushukai Chiba Tokushukai Hospital | Funabashi-shi | |
| Japan | Gifu Prefectural General Medical Center | Gifu | |
| Japan | National Hospital Organization Mito Medical Center | Higashiibaraki-gun | |
| Japan | Hirosaki University Hospital | Hirosaki-shi | |
| Japan | Hiroshima University Hospital | Hiroshima shi | |
| Japan | Hiroshima Prefectural Hospital | Hiroshima-shi | |
| Japan | Tomakomai City Hospital | Hokkaido | |
| Japan | Hyogo Prefectural Amagasaki General Medical Center | Hyogo | |
| Japan | Tokai University Hospital | Isehara | |
| Japan | National Hospital Organization Kanazawa Medical Center | Ishikawa | |
| Japan | Public Central Hospital of Matto Ishikawa | Ishikawa | |
| Japan | Teikyo University Hospital | Itabashi Ku | |
| Japan | Tenyokai Chuo Clinic | Kagoshima-shi | |
| Japan | Fukuoka Tokushukai Hospital | Kasuga-shi | |
| Japan | Sekishinkai Second Kawasaki Saiwai Clinic | Kawasaki-shi | |
| Japan | Kokura Memorial Hospital | Kitakyushu-shi | |
| Japan | Kumamoto University Hospital | Kumamoto | |
| Japan | Saiseikai Kumamoto Hospital | Kumamoto-shi | |
| Japan | Omi Medical Center | Kusatsu-shi | |
| Japan | Kyoto University Hospital | Kyoto-shi | |
| Japan | Ehime Prefectural Central Hospital | Matsuyama-shi | |
| Japan | Seijunkai Mito Hospital | Mito-shi | |
| Japan | Miyakonojo Medical Association Hospital | Miyazaki | |
| Japan | Miyazaki Medical Association Hospital | Miyazaki-shi | |
| Japan | Japanese Red Cross Nagoya Daini Hospital | Nagoya-shi | |
| Japan | Saiseikai Narashino Hospital | Narashino-shi | |
| Japan | Hyogo Medical University Hospital | Nishinomiya-shi | |
| Japan | Miwa Heart Clinic | Nishitokyo-shi | |
| Japan | Okayama University Hospital | Okayama-shi | |
| Japan | Naha City Hospital | Okinawa | |
| Japan | Osaka Police Hospital | Osaka | |
| Japan | Osaka University Hospital | Osaka | |
| Japan | Kindai University Hospital | Osaka Sayama shi | |
| Japan | National Hospital Organization Osaka National Hospital | Osaka-shi | |
| Japan | SAKURABASHi WATANABE HOSPITAL | Osaka-shi | |
| Japan | Kitasato University Hospital | Sagamihara | |
| Japan | Kosekai Iwatsuki-minami Hospital | Saitama-shi | |
| Japan | Matsuda Hospital | Sapporo-shi | |
| Japan | Miyanomori Memorial Hospital | Sapporo-shi | |
| Japan | Tohoku University Hospital | Sendai shi | |
| Japan | Showa University Hospital | Shinagawa | |
| Japan | Tokyo Women's Medical University Hospital | Shinjuku-ku | |
| Japan | National Cerebral and Cardiovascular Center | Suita-Shi | |
| Japan | Takatsuki Red Cross Hospital | Takatsuki-shi | |
| Japan | Kenshinkai Minamino Cardiovascular Hospital | Tokyo | |
| Japan | Kyorin University Hospital | Tokyo | |
| Japan | Nihon University Itabashi Hospital | Tokyo | |
| Japan | Nippon Medical School Hospital | Tokyo | |
| Japan | Ome Medical Center | Tokyo | |
| Japan | The Cardiovascular Institute Hospital | Tokyo | |
| Japan | Tokyo Medical University Hospital | Tokyo | |
| Japan | Oji General Hospital | Tomakomai | |
| Japan | Fujita Health University Hospital | Toyoake | |
| Japan | Uwajima City Hospital | Uwajima-shi | |
| Japan | Yokohama City University Medical Center | Yokohama | |
| Japan | Yokohama Rosai Hospital | Yokohama | |
| Japan | Oita University Hospital | Yufu | |
| Korea, Republic of | Hallym University Sacred Heart Hospital | Anyang-si | |
| Korea, Republic of | Dong-A University Hospital | Busan | |
| Korea, Republic of | Inje University Busan Paik Hospital | Busan | |
| Korea, Republic of | Pusan National University Hospital | Busan | |
| Korea, Republic of | Chungbuk National University Hospital | Cheongju-si | |
| Korea, Republic of | Kangwon National University Hospital | Chuncheon | |
| Korea, Republic of | Keimyung University Dongsan Hospital | Daegu | |
| Korea, Republic of | Chungnam National University Hospital | Daejeon | |
| Korea, Republic of | Inje University Ilsan Paik Hospital | Goyang-si | |
| Korea, Republic of | Hanyang University Guri Hospital | Guri-Si | |
| Korea, Republic of | Chonnam National University Hospital | Gwangju | |
| Korea, Republic of | CHA Bundang Medical Center, CHA University | Gyeonggi-do | |
| Korea, Republic of | Inha University Hospital | Incheon | |
| Korea, Republic of | Seoul National University Bundang Hospital | Seongnam | |
| Korea, Republic of | Asan Medical Center | Seoul | |
| Korea, Republic of | Ewha Womans University Mokdong Hospital | Seoul | |
| Korea, Republic of | Hanyang University Hospital | Seoul | |
| Korea, Republic of | Korea University Anam Hospital | Seoul | |
| Korea, Republic of | Korea University Guro Hospital | Seoul | |
| Korea, Republic of | Samsung Medical Center | Seoul | |
| Korea, Republic of | Seoul National University Hospital | Seoul | |
| Korea, Republic of | Severance Hospital Yonsei University Health System | Seoul | |
| Korea, Republic of | The Catholic University of Korea Seoul St Mary s Hospital | Seoul | |
| Korea, Republic of | Ajou University Hospital | Suwon | |
| Korea, Republic of | WonJu Severance Christian Hospital | Wonju | |
| Korea, Republic of | Yongin Severance Hospital | Yongin si | |
| Latvia | Daugavpils Regional Hospital | Daugavpils | |
| Latvia | Riga East Clinical University Hospital | Riga | |
| Lithuania | Kaunas Clinical Hospital, Public Institution | Kaunas | |
| Lithuania | Klinikiniai sprendimai JSC | Kaunas | |
| Lithuania | Saules Seimos Medicinos Centras, JSC | Kaunas | |
| Lithuania | Klaipeda Seamen's Hospital, Public Institution | Klaipeda | |
| Lithuania | Inlita, JSC | Vilnius | |
| Lithuania | Inmedica, JSC | Vilnius | |
| Lithuania | Vilnius University Hospital Santariskiu Clinic, Public Institution | Vilnius | |
| Lithuania | Vilnius University Hospital Santariskiu Clinic, Public Institution | Vilnius | |
| Malaysia | Hospital Sultanah Bahiyah | Alor Setar | |
| Malaysia | Queen Elizabeth II Hospital | Kota Kinabalu | |
| Malaysia | Institut Jantung Negara | Kuala Lumpur | |
| Malaysia | Hospital Seri Manjung | Seri Manjung | |
| Malaysia | Hospital Taiping | Taiping | |
| Netherlands | Noordwest Ziekenhuisgroep | Alkmaar | |
| Netherlands | ZGT Cardioresearch | Almelo | |
| Netherlands | Meander Medisch Centrum | Amersfoort | |
| Netherlands | Onze Lieve Vrouwe Gasthuis | Amsterdam | |
| Netherlands | Reinier de Graaf Gasthuis | Delft | |
| Netherlands | Deventer Ziekenhuis | Deventer | |
| Netherlands | Slingeland Ziekenhuis | Doetinchem | |
| Netherlands | Ziekenhuis Gelderse Vallei | Ede | |
| Netherlands | Catharina Ziekenhuis | Eindhoven | |
| Netherlands | Groene Hart Ziekenhuis | Gouda | |
| Netherlands | Atrium Med.Centrum Heerlen - Afd.Interne - INT | Heerlen | |
| Netherlands | Elkerliek Ziekenhuis | Helmond | |
| Netherlands | Alrijne Ziekenhuis Leiden ; Cardiology | Leiderdorp | |
| Netherlands | St. Antonius Ziekenhuis Nieuwegein | Nieuwegein | |
| Netherlands | Radboudumc | Nijmegen | |
| Netherlands | Ikazia Ziekenhuis | Rotterdam | |
| Netherlands | Sint Franciscus Gasthuis | Rotterdam | |
| Netherlands | Jeroen Bosch Ziekenhuis | s-Hertogenbosch | |
| Netherlands | D & A Research | Sneek | |
| Netherlands | ETZ Elisabeth | Tilburg | |
| Netherlands | Maxima Medisch Centrum | Veldhoven | |
| Netherlands | Gelre Ziekenhuizen Zutphen | Zutphen | |
| New Zealand | Auckland City Hospital | Auckland | |
| New Zealand | North Shore Hospital | Auckland | |
| New Zealand | University of Otago | Christchurch | |
| New Zealand | Dunedin Public Hospital | Dunedin | |
| New Zealand | Waikato Hospital | Hamilton | |
| New Zealand | Hawkes Bay Hospital | Hastings | |
| New Zealand | Taranaki Base Hospital | New Plymouth | |
| New Zealand | Rotorua Hospital | Rotorua | |
| New Zealand | Tauranga Hospital | Tauranga | |
| Poland | Centrum Medyczne Intercor Sp z o o | Bydgoszcz | |
| Poland | Centrum Medyczne PRATIA Bydgoszcz | Bydgoszcz | |
| Poland | IN VIVO Sp. z o.o | Bydgoszcz | |
| Poland | NZOZ Centrum Medyczne KERmed | Bydgoszcz | |
| Poland | Centrum Medyczne Pratia Chojnice | Chojnice | |
| Poland | DIAB SERWIS Popenda Sp. Jawna Specjalistyczna Przychodnia Lekarska | Chorzow | |
| Poland | M2M Badania Kliniczne | Chorzow | |
| Poland | Centrum Medyczne MBB-MED | Chrzanow | |
| Poland | NZOZ Twoje Zdrowie El | Elblag | |
| Poland | Poradnia Kardiologiczna Jaroslaw Jurowiecki | Gdansk | |
| Poland | NZOZ Procordis Pawel Miekus | Gdynia | |
| Poland | Private Practice - Dr. Krzysztof Cymerman | Gdynia | |
| Poland | MCBK Iwona Czajkowska Anna Podrazka- Szczepaniak S.C. | Grodzisk Mazowiecki | |
| Poland | Centrum Medyczne Pratia Jelenia Gora | Jelenia Góra | |
| Poland | Centrum Medyczne Pratia Katowice | Katowice | |
| Poland | Clinical Medical Research Sp. z o.o. | Katowice | |
| Poland | Kardio Klinika Brynow | Katowice | |
| Poland | Silmedic sp. z o.o | Katowice | |
| Poland | Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego | Kielce | |
| Poland | Centrum Medyczne Linden | Krakow | |
| Poland | Centrum Medyczne Zdrowa J. Trebacz W. Zajdel s.j. | Krakow | |
| Poland | Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska | Krakow | |
| Poland | Krakowskie Centrum Medyczne Sp z o o NZOZ | Krakow | |
| Poland | Oddzial Ortopedii i Traumatologii Narzadu Ruchu Szpital Specjalistyczny im. Ludwika Rydygiera | Krakow | |
| Poland | B.Miklaszewicz&D.Dabrowski CARDIMED Spolka Jawna | Legnica | |
| Poland | Centrum Medyczne AMED oddzial w Lodzi | Lodz | |
| Poland | Indywidualna Specjalistyczna Praktyka Lekarska | Lodz | |
| Poland | NZOZ ALL-MED Centrum Medyczne Specjalistyczne Gabinety Lekarskie | Lodz | |
| Poland | SANTA FAMILIA Centrum Badan, Profilaktyki i Leczenia | Lodz | |
| Poland | Lowickie Centrum Kardiologii | Lowicz | |
| Poland | ETG Lublin | Lublin | |
| Poland | KO-MED Centra Kliniczne LUBLIN | Lublin | |
| Poland | FutureMeds Olsztyn | Olsztyn | |
| Poland | Ostrowieckie Centrum Medyczne Spolka Cywilna Anna Olech-Cudzik, Krzysztof Cudzik | Ostrowiec Swietokrzyski | |
| Poland | Medicome Sp. Z O.O. | Oswiecim | |
| Poland | NZOZ Heureka | Piaseczno | |
| Poland | Med-Polonia Sp. z o.o. | Poznan | |
| Poland | NZOZ NEURO-KARD Ilkowski i Partnerzy Sp. Partnerska Lekarzy | Poznan | |
| Poland | Wojewodzki Szpital im Sw Ojcia Pio w Przemyslu | Przemysl | |
| Poland | Janusz Spyra Specjalistyczna Praktyka Lekarska | Ruda Slaska | |
| Poland | Centrum Medyczne Medyk | Rzeszow | |
| Poland | ETG Siedlce | Siedlce | |
| Poland | Centrum Medyczne Ogrodowa sp. z o.o. | Skierniewice | |
| Poland | FutureMeds Targowek | Warsaw | |
| Poland | FutureMeds Warszawa Centrum | Warsaw | |
| Poland | ETG Warszawa | Warszawa | |
| Poland | CM Sedimed Wroclaw | Wroclaw | |
| Poland | ETG Zamosc | Zamosc | |
| Poland | KO-MED Centra Kliniczne Zamosc | Zamosc | |
| Portugal | Centro Hospitalar Cova da Beira, EPE - Hospital Pêro da Covilhã | Covilha | |
| Portugal | Hospital Distrital Fig Da Foz Gala | Figueira da Foz | |
| Portugal | Centro Hospitalar de Lisboa Norte Hospital Santa Maria | Lisboa | |
| Portugal | Centro Hospitalar Lisboa Ocidental - Hospital São Fracisco Xavier | Lisboa | |
| Portugal | Centro Hospitalar de Entre o Douro e Vouga, E.P.E | Santa Maria da Feira | |
| Portugal | Largo da Igreja Velha Edifício CCA | Torres Novas | |
| Portugal | Centro Hospitalar de Vila Nova de Gaia Espinho E P E | Vila Nova de Gaia | |
| Portugal | Centro Hospitalar de Trás os Montes e Alto Douro- Vila Real | Vila Real | |
| Romania | CMI Cardiologie Dr. Calin Pop | Baia Mare | |
| Romania | Spitalul Judetean de Urgenta Braila | Braila | |
| Romania | Centrul Medical de Diagnostic si Tratament Ambulator NEOMED | Brasov | |
| Romania | Centrul Medical Unirea SRL | Brasov | |
| Romania | Institutul de urgenta pentru Boli Cardiovasculare Prof. Dr. C.C. Iliescu | Bucharest | |
| Romania | Spitalul Clinic de Urologie Prof. Dr. Theodor Burghele | Bucharest | |
| Romania | Clinica Medicala Data Plus SRL | Bucuresti | |
| Romania | S C Delta Health Care S R L | Bucuresti | |
| Romania | Spitalul Angiocare SRL | Cluj-Napoca | |
| Romania | Cardiomed SRL | Iasi | |
| Romania | Institutul de Boli Cardiovasculare Iasi | Iasi | |
| Romania | Spitalul Clinic Judetean de Urgenta Oradea | Oradea | |
| Romania | SAL MED Pitesti | Pitesti | |
| Romania | Spitalul Clinic Judetean Sibiu | Sibiu | |
| Romania | Cabinet Medical Cardiologie Cojocariu Titel Razvan | Suceava | |
| Romania | Cmi Dr Podoleanu Cristian | Targu Mures | |
| Romania | Spitalul Clinic Judetean de Urgenta Targu Mures | Tg. Mures | |
| Romania | Clinica Medicaliss | Timisoara | |
| Serbia | University Clinical Center of Serbia | Belgrade | |
| Serbia | University Clinical Hospital Center Dr Dragisa Misovic- Dedi | Belgrade | |
| Serbia | Clinical Center of Kragujevac | Kragujevac | |
| Serbia | Clinical Center Nis | Nis | |
| Serbia | Institute for Treatment and Rehabilitation Niska Banja | Niska Banja | |
| Serbia | General Hospital Pancevo | Pancevo | |
| Serbia | General Hospital Smederevo | Smederevo | |
| Serbia | General Hospital Sremska Mitrovica | Sremska Mitrovica | |
| Serbia | Health Center Zajecar | Zajecar | |
| Slovakia | Alian s.r.o. | Bardejov | |
| Slovakia | Thyreomedical s r o | Bardejov | |
| Slovakia | Cardioconsult s.r.o. | Bratislava | |
| Slovakia | Kardiovaskularne centrum, s.r.o. | Bratislava | |
| Slovakia | Narodny ustav srdcovych a cievnych chorob | Bratislava | |
| Slovakia | Univerzitna nemocnica Bratislava | Bratislava | |
| Slovakia | Veria, s.r.o Kardiologicka ambulancia | Bratislava | |
| Slovakia | Nemocnica s poliklinikou Brezno | Brezno | |
| Slovakia | KARDIO-ONKOLOGIA s.r.o. Kardiologicka ambulancia | Dolny Kubin | |
| Slovakia | Východoslovenský Ústav Srdcových A Cievnych Chorôb, A.S. | Košice | |
| Slovakia | Cardio D&R, s.r.o. | Kosice | |
| Slovakia | Kardiologicka ambulancia Medicalgroup s.r.o. | Kosice | |
| Slovakia | IN-DIA s.r.o. | Lucenec | |
| Slovakia | Kardio 1 S.R.O. | Lucenec | |
| Slovakia | Kardiomed, S.R.O. | Lucenec | |
| Slovakia | Kardiologicka ambulancia MEDI M&M s.r.o. | Moldava nad Bodvou | |
| Slovakia | Fakultna nemocnica Nitra | Nitra | |
| Slovakia | Cardioinvest s.r.o. | Nove Zamky | |
| Slovakia | Oddelenie dermatovenerológie FNsP J. A. Reimana Prešov | Prešov | |
| Slovakia | Medispol s.r.o Interna a kardiologicka ambulancia | Presov | |
| Slovakia | Interna SK s.r.o. | Svidnik | |
| Slovakia | MEDIVASA s.r.o. | Zilina | |
| South Africa | Tread Research | Cape Town | |
| South Africa | Johese Clinical Research | Centurion | |
| South Africa | Garda, RA | Johannesburg | |
| South Africa | DJW Research | Krugersdorp | |
| South Africa | Clinical Research Unit, University of Pretoria | Pretoria | |
| South Africa | Into Research | Pretoria | |
| South Africa | Dr J.M. Engelbrecht Trial Site | Somerset West | |
| South Africa | Helderberg Research Institute | Somerset West | |
| South Africa | Mediclinic Victoria Hospital | Tongaat | |
| South Africa | Clinical Projects Research SA (PTY) LTD | Worcester | |
| Spain | Hosp. Univ. A Coruna | A Coruña | |
| Spain | Hosp. Gral. Univ. de Alicante | Alicante | |
| Spain | Hosp. de La Santa Creu I Sant Pau | Barcelona | |
| Spain | Hosp. Del Mar | Barcelona | |
| Spain | Hosp. Univ. Virgen de La Arrixaca | El Palmar | |
| Spain | Hosp. Univ. Arnau de Vilanova de Lleida | Lleida | |
| Spain | Hosp. Univ. de La Princesa | Madrid | |
| Spain | Hosp. Univ. La Paz | Madrid | |
| Spain | Hosp. Virgen de La Victoria | Malaga | |
| Spain | Hosp. de Manises | Manises | |
| Spain | Hosp. Clinico Univ. de Santiago | Santiago de Compostela | |
| Spain | Hosp. Clinico Univ. de Valencia | Valencia | |
| Spain | Hosp. Clinico Univ. de Valencia | Valencia | |
| Taiwan | Changhua Christian Hospital | Changhua | |
| Taiwan | E-DA Hospital | Kaohsiung | |
| Taiwan | Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | |
| Taiwan | Far Eastern Memorial Hospital | New Taipei | |
| Taiwan | Mackay Memorial Hospital | New Taipei | |
| Taiwan | China Medical University Hospital | Taichung | |
| Taiwan | Cathay General Hospital | Taipei | |
| Taiwan | National Taiwan University Hospital | Taipei | |
| Taiwan | Taipei Municipal Wanfang Hospital | Taipei | |
| Taiwan | Tri-Service General Hospital | Taipei | |
| Taiwan | Taipei Veterans General Hospital | Taipei City | |
| Taiwan | Chang Gung Memorial Hospital- Linkou | Taoyuan County | |
| United Kingdom | Bristol Royal Infirmary | Bristol | |
| United Kingdom | Golden Jubilee National Hospital | Clydebank | |
| United Kingdom | Dorset County Hospital | Dorchester | |
| United Kingdom | Wycombe Hospital | High Wycombe | |
| United Kingdom | Lincoln County Hospital | Lincoln | |
| United Kingdom | Barts Hospital | London | |
| United Kingdom | Northern General Hospital | Sheffield | |
| United Kingdom | Royal Cornwall Hospital | Truro | |
| United Kingdom | Wrightington Hospital,Wrightington, Wigan and Leigh NHS Trus | Wigan | |
| United States | Summa Health System | Akron | Ohio |
| United States | Advanced Cardiovascular, LLC | Alexander City | Alabama |
| United States | Cambridge Medical Trials | Alexandria | Louisiana |
| United States | Orlando Heart Specialists | Altamonte Springs | Florida |
| United States | Amarillo Heart Clinical Research Institute | Amarillo | Texas |
| United States | PharmaTex Research | Amarillo | Texas |
| United States | AnMed Health | Anderson | South Carolina |
| United States | Internal Medicine Associates of Anderson | Anderson | South Carolina |
| United States | Luminis Health Anne Arundel Medical Center | Annapolis | Maryland |
| United States | Asheville Cardiology Associates | Asheville | North Carolina |
| United States | Grady Memorial Hospital | Atlanta | Georgia |
| United States | Piedmont Heart Institute | Atlanta | Georgia |
| United States | Aurora Denver Cardiology Associates | Aurora | Colorado |
| United States | Ascension Texas Cardiovascular | Austin | Texas |
| United States | Bakersfield Memorial Hospital | Bakersfield | California |
| United States | Ascension Medical Group - St. John Clinic Infectious Disease | Bartlesville | Oklahoma |
| United States | Suburban Hospital | Bethesda | Maryland |
| United States | Vitality Clinical Research | Beverly Hills | California |
| United States | Ascension St. Vincent's Health System | Birmingham | Alabama |
| United States | Bloomington Hospital | Bloomington | Indiana |
| United States | HealthPartners Institute | Bloomington | Minnesota |
| United States | Grace Research, LLC - Bossier City | Bossier City | Louisiana |
| United States | Bay Area Cardiology Associates, P.A. - Brandon Office | Brandon | Florida |
| United States | Bridgeport Hospital | Bridgeport | Connecticut |
| United States | Advanced Heart Care, LLC | Bridgewater | New Jersey |
| United States | Cardiac Care & Vascular Medicine, PLLC | Bronx | New York |
| United States | Burke Internal Medicine and Research | Burke | Virginia |
| United States | Medical Research Specialists | Chalmette | Louisiana |
| United States | Chambersburg Hospital | Chambersburg | Pennsylvania |
| United States | Northwestern University | Chicago | Illinois |
| United States | Chula Vista Cardiac Clinic | Chula Vista | California |
| United States | Sharp Chula Vista Medical Center | Chula Vista | California |
| United States | The Lindner Clinical Trial Center | Cincinnati | Ohio |
| United States | Clearwater Cardiovascular Consultants | Clearwater | Florida |
| United States | Louis Stokes Cleveland VA Med Ctr | Cleveland | Ohio |
| United States | Kootenai Medical Center | Coeur d'Alene | Idaho |
| United States | Johns Hopkins University | Columbia | Maryland |
| United States | MUSC Health Heart Vascular Columbia Medical Park DT III | Columbia | South Carolina |
| United States | The Curators of the University of Missouri on behalf of University of Missouri Health Care | Columbia | Missouri |
| United States | Columbus Regional Research Institute | Columbus | Georgia |
| United States | St. Elizabeth Physicians | Crittenden | Kentucky |
| United States | Atlanta Heart Specialists | Cumming | Georgia |
| United States | Baylor Research Institute | Dallas | Texas |
| United States | Texas Health Dallas | Dallas | Texas |
| United States | Western Connecticut Health Network/Danbury Hospital | Danbury | Connecticut |
| United States | Dayton Heart Center | Dayton | Ohio |
| United States | Cardiology Associates Research Company | Daytona Beach | Florida |
| United States | Cardiology Consultants | Daytona Beach | Florida |
| United States | Accel Research Sites | DeLand | Florida |
| United States | Aurora Denver Cardiology Associates | Denver | Colorado |
| United States | SEC Clinical Research | Dothan | Alabama |
| United States | Alpine Research Organization | Farmington | Utah |
| United States | Flint Clinical Research | Flint | Michigan |
| United States | Plaza Medical Center of Fort Worth | Fort Worth | Texas |
| United States | Mission Cardiovascular Research Institute | Fremont | California |
| United States | Northeast Georgia Heart Center | Gainesville | Georgia |
| United States | The Cardiac & Vascular Institute Research Foundation | Gainesville | Florida |
| United States | University of Florida College of Medicine | Gainesville | Florida |
| United States | Mercy Gilbert Medical Center | Gilbert | Arizona |
| United States | Paradise Clinical Research Group LLC | Glendora | California |
| United States | Guilford Neurologic Associates | Greensboro | North Carolina |
| United States | St. Francis Physician Services, Inc, DBA Upstate Cardiology Research | Greenville | South Carolina |
| United States | Clinical Investigation Specialists | Gurnee | Illinois |
| United States | Cardiovascular Associates of the Delaware Valley | Haddon Heights | New Jersey |
| United States | Chicago Medical Research, LLC | Hazel Crest | Illinois |
| United States | Cardiovascular Institute of the South | Houma | Louisiana |
| United States | Baylor College of Medicine | Houston | Texas |
| United States | East Texas Cardiology, PA | Houston | Texas |
| United States | Novel Research LLC | Houston | Texas |
| United States | Primecare Medical Group | Houston | Texas |
| United States | HH Heart Center and Heart Center | Huntsville | Alabama |
| United States | St. Vincent Medical Group, Inc. | Indianapolis | Indiana |
| United States | Jackson Clinic | Jackson | Tennessee |
| United States | Jackson Madison County General Hospital | Jackson | Tennessee |
| United States | East Coast Institute for Research | Jacksonville | Florida |
| United States | Jamaica Hospital Medical Center | Jamaica | New York |
| United States | Wellmont CVA Heart Institute | Johnson | Tennessee |
| United States | West Houston Area Clinical Trial Consultants LLC | Katy | Texas |
| United States | Holston Medical Group | Kingsport | Tennessee |
| United States | Westchester Medical Center Advanced Physician Services PC | Kingston | New York |
| United States | Texas Cardiology Research Center | Kingwood | Texas |
| United States | East Tennessee Heart Consultants | Knoxville | Tennessee |
| United States | Watson Clinic | Lakeland | Florida |
| United States | Sparrow Clinical Research Institute | Lansing | Michigan |
| United States | Clearwater Cardiovascular Consultants | Largo | Florida |
| United States | Laurelton Heart Specialist, PC | Laurelton | New York |
| United States | Clinical Trials of America | Lenoir | North Carolina |
| United States | Arkansas Heart Hospital | Little Rock | Arkansas |
| United States | Miller Children's at Long Beach Medical Center | Long Beach | California |
| United States | Los Angeles Cardiology Associates | Los Angeles | California |
| United States | Kentuckyone Health Neurology Associates | Louisville | Kentucky |
| United States | Virtua Medical Group, PA | Marlton | New Jersey |
| United States | Advanced Medical Research | Maumee | Ohio |
| United States | Merced Vein and Vascular Center | Merced | California |
| United States | Miami Clinical Research | Miami | Florida |
| United States | Reliant Medical Research | Miami | Florida |
| United States | Suncoast Research Associates, LLC | Miami | Florida |
| United States | Crystal Run Healthcare LLP | Middletown | New York |
| United States | NYU Langone Hospital Long Island | Mineola | New York |
| United States | Trinity Medical Group | Minot | North Dakota |
| United States | Ascension Sacred Heart Hospital | Miramar Beach | Florida |
| United States | CB Flock Research Corporation | Mobile | Alabama |
| United States | IU Health Ball Memorial Hospital | Muncie | Indiana |
| United States | Midwest Cardiovascular Institute | Naperville | Illinois |
| United States | Saint Thomas Health | Nashville | Tennessee |
| United States | Ochsner Health System | New Orleans | Louisiana |
| United States | Suncoast Clinical Research | New Port Richey | Florida |
| United States | Lenox Hill Hospital | New York | New York |
| United States | Weill Cornell Medical College | New York | New York |
| United States | Cardiology Physicians | Newark | Delaware |
| United States | Capital Area Research | Newport | Pennsylvania |
| United States | Radin Cardiovascular Medical Group | Newport Beach | California |
| United States | California Medical Research Associates, Inc. | Northridge | California |
| United States | Valley Clinical Trials, Inc. | Northridge | California |
| United States | Prairie Education And Research Cooperative | O'Fallon | Illinois |
| United States | Odessa Heart Institute | Odessa | Texas |
| United States | Oklahoma Heart Hospital | Oklahoma City | Oklahoma |
| United States | South Oklahoma Heart Research | Oklahoma City | Oklahoma |
| United States | Olive Branch Family Medical Center | Olive Branch | Mississippi |
| United States | Central Florida Medical Associates | Orange City | Florida |
| United States | Owensboro Medical Practice | Owensboro | Kentucky |
| United States | Cardiology Partners Clinical Research Institute | Palm Beach Gardens | Florida |
| United States | Desert Oasis Health Care | Palm Springs | California |
| United States | Havana Research Institute LLC | Pasadena | California |
| United States | Cardiology Consultants | Pensacola | Florida |
| United States | Methodist Medical Center of Illinois | Peoria | Illinois |
| United States | Michigan Heart & Vascular Institute | Petoskey | Michigan |
| United States | Penn Presbyterian Medical Center | Philadelphia | Pennsylvania |
| United States | Arizona Arrhythmia Research Center | Phoenix | Arizona |
| United States | Arizona Heart Hospital | Phoenix | Arizona |
| United States | Valleywise Health Medical Center | Phoenix | Arizona |
| United States | Pinehurst Medical Clinic Inc | Pinehurst | North Carolina |
| United States | Hudson Valley Cardiovascular Practice, PC | Pittsburgh | Pennsylvania |
| United States | VA Pittsburgh Healthcare System | Pittsburgh | Pennsylvania |
| United States | North Broward Hospital District | Pompano Beach | Florida |
| United States | Charlotte Heart Group Research Center | Port Charlotte | Florida |
| United States | Cardiovascular Associates | Powell | Tennessee |
| United States | Eisenhower Desert Cardiology Center | Rancho Mirage | California |
| United States | Black Hills Cardiovascular Research | Rapid City | South Dakota |
| United States | Roanoke Heart Institute PLC | Roanoke | Virginia |
| United States | OSF HealthCare Cardiovascular Institute | Rockford | Illinois |
| United States | Shady Grove Office | Rockville | Maryland |
| United States | Coastal Cardiology Consultants | Safety Harbor | Florida |
| United States | St. Louis Heart and Vascular | Saint Louis | Missouri |
| United States | Washington University School Of Medicine | Saint Louis | Missouri |
| United States | Heart and Vascular Institute of Florida | Saint Petersburg | Florida |
| United States | Tidal Health Peninsula Regional Inc. | Salisbury | Maryland |
| United States | Sun Research Institute | San Antonio | Texas |
| United States | San Diego Cardiac Center | San Diego | California |
| United States | Sanford Cardiology | Sanford | North Carolina |
| United States | Syrentis Clinical Research | Santa Ana | California |
| United States | Cardiovascular Center of Sarasota | Sarasota | Florida |
| United States | Donald Guthrie Foundation | Sayre | Pennsylvania |
| United States | HonorHealth Neurology | Scottsdale | Arizona |
| United States | Louisiana State University Health Sciences Center | Shreveport | Louisiana |
| United States | Pierremont Cardiology | Shreveport | Louisiana |
| United States | Revival Research Institute LLC | Southgate | Michigan |
| United States | Springfield Clinic 1st | Springfield | Illinois |
| United States | The Heart House | Springfield | Ohio |
| United States | Cardiology Associates of Fairfield County | Stamford | Connecticut |
| United States | Ramin Manshadi, MD | Stockton | California |
| United States | Southwest Medical Clinic | Sugar Land | Texas |
| United States | Universal Research Group, LLC | Tacoma | Washington |
| United States | Adtremed Inc | Tampa | Florida |
| United States | Florida Hospital Tampa | Tampa | Florida |
| United States | Helping Hands Health Center dba Helping Hands Evolution Research | Tampa | Florida |
| United States | University of South Florida | Tampa | Florida |
| United States | Cardiology Consultants of South Georgia Inc | Thomasville | Georgia |
| United States | Northwest Houston Clinical Research | Tomball | Texas |
| United States | UCLA School of Medicine | Torrance | California |
| United States | Spectrum Clinical Research, Inc. | Towson | Maryland |
| United States | Oakland Medical Research | Troy | Michigan |
| United States | PriMed Physicians, A Member of NE Medical Group | Trumbull | Connecticut |
| United States | St John Health System Inc | Tulsa | Oklahoma |
| United States | Cardiology Associates of North Mississippi | Tupelo | Mississippi |
| United States | Cardiology Associates Medical Group | Ventura | California |
| United States | North County Internal Medicine | Vista | California |
| United States | Baylor Scott & White Research Institute | Waco | Texas |
| United States | John Muir Physician Network Clin. Research Center | Walnut Creek | California |
| United States | George Washington University School of Medicine | Washington | District of Columbia |
| United States | Wausau Hospital | Wausau | Wisconsin |
| United States | Allegiance Reserach Specialists, LLC | Wauwatosa | Wisconsin |
| United States | Cardiology Partners Clinical Research Institute | Wellington | Florida |
| United States | Clinical Trials of America | West Monroe | Louisiana |
| United States | Paradigm Clinical Research Centers, Inc. | Wheat Ridge | Colorado |
| United States | Wilmington Health Associates | Wilmington | North Carolina |
| United States | Cardiology Consultants of Philadelphia | Yardley | Pennsylvania |
| United States | York Hospital | York | Pennsylvania |
| United States | Genesis HealthCare System | Zanesville | Ohio |
| Lead Sponsor | Collaborator |
|---|---|
| Janssen Research & Development, LLC | Bristol-Myers Squibb |
United States, Argentina, Australia, Belgium, Brazil, Bulgaria, Canada, Chile, China, Croatia, Czechia, Denmark, Estonia, France, Germany, Greece, Hungary, Israel, Italy, Japan, Korea, Republic of, Latvia, Lithuania, Malaysia, Netherlands, New Zealand, Poland, Portugal, Romania, Serbia, Slovakia, South Africa, Spain, Taiwan, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Time to the First Occurrence of Composite Endpoint of Stroke and Non-central nervous system (CNS) Systemic Embolism | Time to the first occurrence of composite endpoint of stroke and non-CNS systemic embolism will be reported. | Up to 4 years | |
| Secondary | Time to the First Occurrence of International Society of Thrombosis and Hemostasis (ISTH) Major Bleeding | Time to the first occurrence of ISTH major bleeding will be reported. | Up to 4 years | |
| Secondary | Time to the First Occurrence of the Composite of ISTH Major and Clinically Relevant Non-major (CRNM) Bleeding | Time to the first occurrence of the composite of ISTH major and CRNM bleeding will be reported. | Up to 4 years | |
| Secondary | Time to the First Occurrence of Composite Endpoint of Cardiovascular (CV) Death, Myocardial Infarction (MI), Stroke, and Non-CNS Systemic Embolism | Time to the first occurrence of composite endpoint of CV death, MI, stroke, and non-CNS systemic embolism will be reported. | Up to 4 years | |
| Secondary | Time to CV Death | Time to CV death will be reported. | Up to 4 years | |
| Secondary | Time to the First Occurrence of Composite Endpoint of All-cause Death, MI, Stroke and Non-CNS Systemic Embolism | Time to the first occurrence of composite endpoint of all-cause death, MI, stroke and Non-CNS systemic embolism will be reported. | Up to 4 years | |
| Secondary | Time to the First Occurrence of Composite Endpoint of CV Death, MI, Stroke, Acute Limb Ischemia (ALI), and Urgent Hospitalization for Vascular cause of Ischemic Nature | Time to the first occurrence of composite endpoint of CV death, MI, stroke, ALI [any unanticipated revascularization or amputation of ischemic limb]), and urgent hospitalization for vascular cause of ischemic nature (including deep vein thrombosis [DVT] and pulmonary embolism [PE]) will be reported. | Up to 4 years |
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