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DOCE Study Interaction Between Direct Oral Anticoagulants and Drug-metabolizing Enzyme Inducers

Atrial Fibrillation Clinical Trial

Official title:
Interaction Between Direct Oral Anticoagulants and Drug-metabolizing Enzyme Inducers

Clinical Trial Summary

Aim of the study is to investigate whether the influence of drugs inducing of CYP 3A4 isoenzyme of CYP450 and P-gp transporter significantly affect plasma levels of DOACs in patients with NVAF and venous thromboembolism

Clinical Trial Description

Aim of the study is to investigate whether the influence of drugs inducing of CYP 3A4 isoenzyme of CYP450 and P-gp transporter significantly affect plasma levels of DOACs in patients with NVAF and venous thromboembolism. Also the difference between DOACs inducing both CYP3A4 and P-gp transporter (rivaroxaban and apixaban) and DOACs inducing the P-pg transporter only will be investigated. Thriomboembolic and bleeding events during the study duration will be registered and correlated to the measured DOAC plasma levels. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05750680
Study type Observational [Patient Registry]
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Erica De Candia, MD
Phone 0630156329
Email erica.decandia@policlinicogemelli.it
Status Recruiting
Phase
Start date May 13, 2021
Completion date April 1, 2023
View Details
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