Strategies in Patients Undergoing Repeat AF Ablation — TRAP-AF  

Atrial Fibrillation Clinical Trial

Official title: Strategies in Patients Undergoing Repeat AF Ablation

Status Terminated

Clinical Trial Summary

The aim of the proposed research project is to compare the efficacy of three different ablation strategies in patients with atrial fibrillation (AF) who are undergoing their first repeat catheter ablation for recurrent AF.

Clinical Trial Description

Reconnection of the pulmonary veins (PV) is generally responsible for AF recurrence in most cases. However, in a growing subset of patients undergoing repeat ablation for recurrent AF, the PVs are chronically isolated and no other non-PV triggers of AF can be identified. The investigators have previously shown that empirically ablating at known common non-PV trigger sites for AF can improve arrhythmia free survival beyond PVI. The left atrial (LA) posterior wall is also increasingly being isolated in AF patients undergoing catheter ablation. However, long term arrhythmia free survival in AF patients undergoing LA posterior wall isolation is not consistently better than PVI alone. The objective of this study therefore is to assess whether performing empiric ablation of common non-PV trigger sites or achieving LA posterior wall isolation can improve arrhythmia free survival in AF patients who are undergoing repeat AF ablation and in whom the PV remain chronically isolated and/or do not demonstrate AF. The investigators propose to do this as prospective, randomized three arm study. ;

Related Conditions & MeSH terms

• Atrial Fibrillation

• NCT number: NCT05185310
• Study type: Interventional
• Source: University of Pennsylvania
• Status: Terminated
• Phase: N/A
• Start date: December 13, 2021
• Completion date: February 3, 2023