Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT04884100 |
Other study ID # |
2021-00586 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
September 15, 2021 |
Est. completion date |
July 21, 2023 |
Study information
Verified date |
August 2023 |
Source |
Centre Hospitalier Universitaire Vaudois |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
This research will investigate the PPG signal morphology related to physiological and non-
physiological changes in arrhythmia-related heart rate as well as the performance of the
PPG-based features previously developed within the framework of the Mini-Holter study to
discriminate between several cardiac arrhythmias. To this end, clinical data will be recorded
on patients by using a wrist-based PPG monitor simultaneously with 12-lead ECG and
intracardiac electrogram (EGM) signals at the university hospital in Lausanne. Importantly,
this study will remain purely observational as it will not change the diagnostic and
therapeutic management of the included patients, nor will it interfere with the time course
of the procedures. The aim of enHEART study is to validate on a larger database the ability
of several previously developed PPG-based features to detect a variety of cardiac
arrhythmias.
Description:
The aim of the study is to acquire high quality PPG signals of various types of cardiac
arrhythmias during diagnostic and therapeutic procedures, under controlled conditions (i.e.,
electrophysiology lab), which can be compared beat-to-beat to a concurrently-acquired,
gold-standard reference (12-lead ECG and intracardiac EGM signals), and expert annotations by
CHUV physicians. To this end, a total of 99 patients referred for diagnostic or therapeutic
interventions (ablation) of 9 different types of cardiac arrhythmias at the CHUV will be
enrolled. 11 patients per type of arrhythmia will be included.
The following clinical data will be collected from the electronic file of the patient:
1. Clinical data such as age, gender, weight, size, BMI, blood pressure and heart rate,
cardiovascular risk factors, clinical history
2. Baseline treatment and treatment at time of the electrophysiological procedure
3. Arrhythmia type and arrhythmia-related symptoms
4. Left and right ventricular ejection fraction as provided by the patient's private
cardiologist echocardiogram.
The following paraclinical data will be synchronously collected during the diagnostic and/or
therapeutic intervention in the electrophysiology laboratory:
1. Surface ECG signals
2. Intracardiac EGM signals as provided by the intracardiac catheters used for the
diagnostic and/or therapeutic interventions. Depending on the type of intervention, up
to three different catheters may be used
3. PPG signals as provided by the PPG wrist monitor
The primary objective of our study is to investigate if features extracted from the pulse
morphology of PPG signals (waveform-based features) significantly improve the classification
accuracy of cardiac arrhythmias compared to a classification based on heart rate variation
(HRV) features only.