Atrial Fibrillation Clinical Trial
Official title:
Comparison of Two Strategies for the Management of Atrial Fibrillation After Cardiac Surgery : a Randomized Multicenter Clinical Trial
Postoperative atrial fibrillation is a common complication after cardiac surgery with a rate
of 30%. However, management of postoperative atrial fibrillation is controversial. Two
strategies are recommended : heart rate control using a betablocker or rhythm control with
amiodarone.
Landiolol is a new-generation beta-blocker with a short half-life, which was approved by the
Haute Autorité de Santé to be used in perioperative supra-ventricular tachycardias.
Only one study compared landiolol to amiodarone in the perioperative setting, with a better
hemodynamic tolerance and a higher rate of conversion to sinus rhythm with landiolol. However
this was a single-center and retrospective study.
The aim of our multicenter randomized study is to compare the effectiveness of landiolol in
reducing atrial fibrillation to sinus rhythm compared to amiodarone in the postoperative
period after cardiac surgery.
Randomized clinical study comparing landiolol and amiodarone for treatment of atrial fibrillation following cardiac surgery ;
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