Atrial Fibrillation Clinical Trial
Official title:
Atrial Fibrillation Recurrence Following Cardioversion: the Role of Clinical Factors and Alpha Defensin Levels
Atrial fibrillation and inflammation are strongly correlated. The aim of this study is to evaluate whether inflammation markers (alpha Defensin) predict maintenance of sinus rhythm following cardioversion. A secondary aim is to evaluate the role of Colchicine, an anti-inflammatory medication, in reducing the recurrence rate of atrial fibrillation.
| Status | Not yet recruiting |
| Enrollment | 300 |
| Est. completion date | November 2022 |
| Est. primary completion date | November 2022 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Atrial fibrillation - Candidate for cardioversion Exclusion Criteria: - Colchicine allergy - Hepatic or renal failure |
| Country | Name | City | State |
|---|---|---|---|
| Israel | Hillel Yaffe Medical Center | Hadera |
| Lead Sponsor | Collaborator |
|---|---|
| Hillel Yaffe Medical Center |
Israel,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Recurrence of atrial fibrillation | Atrial fibrillation recurrence rates over the next 12 months will be determined based on medical records and ECG documentation between treatment group (Colchicine) and control group. | 12 months | |
| Secondary | Alpha Defensin levels in patients with recurrence of atrial fibrillation | Alpha Defensin levels will be measured in patients with recurrence of atrial fibrillation and compared to levels in patients without recurrence. | 12 months |
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