Atrial Fibrillation Clinical Trial
Official title:
Correlation of Atrial Fibrillation Recurrence After Bipolar Radiofrequency Ablation With microRNA Expression
The recurrence rate of atrial fibrillation (AF) after bipolar radiofrequency ablation was about 30%. Besides the factors, left atrium diameter, the duration of AF, NT-proBNP, and ejection fraction(EF), some studies demonstrated that the specific microRNA expression (miRNA1, miRNA19,miRNA23, miRNA409 ) showed the significant change in AF patients compared with normal sinus patients, who underwent catheter ablation. Therefore, the correlation of atrial fibrillation recurrence and above-mentioned microRNA after bipolar radiofrequency ablation remained unclear, although bipolar radiofrequency ablation had high rate of sinus.
Numerous studies identify specific microRNA (miRNA) expression profiles associated with
atrial fibrillation (AF), changes in plasmamiRNA expression in pre-and
post-operativeAFpatients who have received catheterisation . The correlation of atrial
fibrillation recurrence and above-mentioned microRNA after bipolar radiofrequency ablation
remain poorly characterized.
This study aimed to reveal disease-related biomarkers by detecting plasmamiRNA expression in
AF patients, and examining the levels of AF-specific miRNAs in patients after bipolar
radiofrequency ablation, in order to help gauge therapeutic effects and assess prognosis.
A total of 50 Han Chinese patients with AF who had received bipolar radiofrequency ablation
recruited to the study. Atrial fibrillation-specific plasma miRNAs were detected by
sequencing and quantitative reverse transcription polymerase chain reaction. According to AF
recurrence rate of about 30%, the expression levels of AF-specific miRNAs were investigated
in15 post-operative AF patients and 35 patients with normal sinus after ablation,to explore
changes in miRNA expression.
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