Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG

Atrial Fibrillation Clinical Trial

Official title:

Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After Coronory Artery Bypass Grafting (CABG) Surgery in Egyptian Patients Receiving Beta Blockers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03871647
• Other study ID #: PhD 53
• Status: Completed
• Start date: March 11, 2019
• Est. completion date: March 7, 2021

Study information

• Verified date: November 2021
• Source: Ain Shams University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients. It is associated with prolonged hospitalization, increased hospital costs, increased complications and mortality rate.

Despite the use of Beta Blockers, approximately 20% of patients develop atrial fibrillation following CABG surgery, suggesting a role for polymorphism in the genes The aim of the present study is to determine the minor allele frequency of some of the genes that affect the beta blockers' response and to determine the association between polymorphism in these genes and the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting in Egyptian patients receiving perioperative beta blockers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 256
• Est. completion date: March 7, 2021
• Est. primary completion date: December 7, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

1. Age above 18 years.

2. Candidates for CABG surgery without a concurrent valve surgery.

3. Patients receiving perioperative beta blockers before new onset of postoperative AF.

Exclusion Criteria:

1. Patients who have either persistent or permanent AF, atrial flutter or atrial tachycardia on ECG obtained on the day of the operation.

2. Serum creatinine >2 mg/dL before the surgery.

3. Uncontrolled thyroid disease.

4. Recent treatment with amiodarone before the occurrence of POAF

Related Conditions & MeSH terms

• Atrial Fibrillation
• Coronary Bypass Graft Surgery

Intervention

Drug:
• Beta blocker
perioperative beta blockers

Locations

Country	Name	City	State
Egypt	The Cardiovascular & Thoracic Academy - Ain Shams University.	Cairo

Sponsors (2)

Lead Sponsor	Collaborator
Ain Shams University	Misr International University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Occurrence of Atrial fibrillation	Atrial fibrillation based on postoperative electrocardiogram. AF diagnostic criteria will include absence of discrete P waves, the RR intervals follow unrepetitive form and the ranges of ventricular rate usually between 90 and 170 beats/min.	within 6 days after the operation