Atrial Fibrillation Clinical Trial
Official title:
Study of Electrophysiological Effects of NACOS and AVK on the Pulmonary Veins and the Left Atrium of Patients Referred for Paroxysmal AF Catheter Ablation
Atrial fibrillation (AF) is the most common cardiac arrhythmias with a constantly growing
prevalence AF. The purpose of paroxysmal AF processing is to control outbreaks from these
pulmonary veins, medicated way (antiarrhythmic) or interventional. Ablation (radiofrequency
or cryotherapy) has become in this context recognized and effective treatment of AF. In
addition, antithrombotic treatments in this context is a major treatments for the prevention
of stroke (stroke). They are most often associated with antiarrhythmic treatment to prevent
recurrence of AF or to slow it during a relapse.
Recent experimental studies have highlighted the direct electrophysiological properties of
dabigatran and rivaroxaban in the pulmonary veins and the left atrium. Dabigatran
demonstrated in this study that it induced a prolongation of potential action in the
pulmonary veins and the left atrium and it decreased the incidence of FA-induced by
stimulation. Conversely, rivaroxaban induces shortening of the action potential in the left
atrium (untested properties in the pulmonary veins). To our knowledge, apixaban and warfarin
have not been studied in this context.
It is therefore possible that some of the new oral anticoagulants (NACOS) or some AVK
(fluindione and warfarin), have direct electrophysiological effects in the pulmonary veins
and on the left atrium and could influence AF recurrences (with effect " antiarrhythmic-like
"or rather a pro-arrhythmic effect) after ablation.A retrospective analysis conducted at the
University Hospital of Caen on very low numbers suggest that patients on dabigatran would
have less pulmonary veins connected in early ablation procedure that patients on warfarin or
rivaroxaban. Despite the limitations inherent in this analysis (very low numbers,
retrospective analysis, unique setting and having studied his own limits), these results are
consistent with the fundamental studies, and thus encourage us to pursue our hypothesis to
obtain more statistical power and reliability in our measurements and results.
We therefore propose the study of the electrophysiological effects of NACOS (apixaban,
dabigatran, rivaroxaban) and warfarin (warfarin and fluindione) on the pulmonary veins and
the left atrium of patients referred for ablation of paroxysmal AF (radiofrequency or
cryotherapy ) the CHU of Caen and Tours and clinic Saint Martin Caen.
n/a
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