Comparison of Circumferential Pulmonary Vein Isolation Alone Versus Linear Ablation in Addition to Circumferential Pulmonary Vein Isolation for Catheter Ablation in Persistent Atrial Fibrillation: Prospective Randomized Controlled Trial

Atrial Fibrillation Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02721121
• Other study ID #: 4-2016-0029
• Status: Recruiting
• Phase: N/A
• Start date: March 2016
• Est. completion date: March 2021

Study information

• Verified date: January 2019
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for persistent atrial fibrillation. After randomization, investigators will conduct circumferential pulmonary vein isolation alone in a group, and additional posterior box isolation and anterior linear ablation in the other group. Investigators will compare clinical recurrence rate, complication rate, and procedure time, etc.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 220
• Est. completion date: March 2021
• Est. primary completion date: March 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients with persistent Atrial fibrillation (20~80 years)

• LA diameter <55mm

• patients possible to anticoagulation and anti arrhythmic drug

Exclusion Criteria:

• Structural cardiac disease

• Contraindication to brain perfusion CT

• Catheter ablation history for AF,

• Cardiac surgery for AF

• active internal bleeding

• Impossible to anticoagulation or antiarrhythmic drug

• valvular AF (MA> GII, Mechanical valve, Mitral valve replacement)

• Patients with severe medical disease

• Expected survival < 1year

• Severe alcoholics, drug addiction

Related Conditions & MeSH terms

• Atrial Fibrillation

Intervention

Procedure:
• circumferential pulmonary vein isolation

• Linear ablation in addiction to circumferential pulmonary vein isolation

Locations

Country	Name	City	State
Korea, Republic of	Severance Cardiovascular Hospital, Yonsei University Health System	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Recurrence of atrial fibrillation after catheter ablation		12 month
Secondary	procedure time		1 day
Secondary	procedure related complication rate		12 month
Secondary	rate of hospitalization		12 month