Atrial Fibrillation Clinical Trial
Official title:
Clinical Study of the Relationship Between Pharmacogenomics and Warfarin Dose in Chinese Patients
1. Title: Clinical study of the relationship between Pharmacogenomics and warfarin dose in
Chinese patients
2. Drug: Warfarin
3. Design: To value the accuracy of warfarin Pharmacogenomics algorithm by the algorithm
calculated dose and actual dose in the Chinese patients.
4. Hypothesis:Pharmacogenomic algorithm guided dose can help to predict warfarin dose in
Chinese patients.
- For the patients who need to use warfarin, detect the "Vitamin K epoxide reductase
complex subunit 1 (VKORC1),cytochrome p450 2C9 (CYP2C9), and cytochrome p450 4F2
(CYP4F2) genotype.
- Record the demographic information: gender, age, height, and weight.
- Record drug combination, complications, and international normalized ratio (INR), liver
function and kidney function or other biochemical test results.
- Put genotypes, demographic information and other clinical information into the
algorithm to calculate warfarin dose for the patients, and compared with the actual
dose.
;
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