Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)

Atrial Fibrillation Clinical Trial

Official title:

Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00833313
• Other study ID #: 2008-P000896
• Status: Recruiting
• Start date: August 2008
• Est. completion date: August 2025

Study information

• Verified date: February 2023
• Source: Brigham and Women's Hospital
• Contact: Jochen D Muehlschlegel, MD
• Phone: 617-732-7330
• Email: jmuehlschlegel[@]partners.org
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

Description:

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

This study seeks to identify regulatory events in atrial myocyte transcription and translation that are altered by germline variation

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 350
• Est. completion date: August 2025
• Est. primary completion date: August 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 99 Years

Eligibility

Inclusion Criteria:

• Age 20-99 years

• Undergoing cardiac surgery

Exclusion Criteria:

• Prior cardiac surgery

• chest radiation

• recent chemotherapy

Related Conditions & MeSH terms

• Atrial Fibrillation

Intervention

Procedure:
• Atrial biopsy
Biopsy of left atrial free wall and possibly left atrial appendage

Locations

Country	Name	City	State
United States	Brigham and Women's Hospital	Boston	Massachusetts

Sponsors (1)

Lead Sponsor	Collaborator
Brigham and Women's Hospital

Country where clinical trial is conducted

United States, 

References & Publications (2)

Sigurdsson MI, Saddic L, Heydarpour M, Chang TW, Shekar P, Aranki S, Couper GS, Shernan SK, Muehlschlegel JD, Body SC. Post-operative atrial fibrillation examined using whole-genome RNA sequencing in human left atrial tissue. BMC Med Genomics. 2017 May 2; — View Citation

Sigurdsson MI, Saddic L, Heydarpour M, Chang TW, Shekar P, Aranki S, Couper GS, Shernan SK, Seidman JG, Body SC, Muehlschlegel JD. Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischem — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gene expression		Immediate