Atrial Fibrillation Clinical Trial
Official title:
Sinus Rhythm Maintenance in Patients With Hypertrophic Cardiomyopathy and Atrial Fibrillation - Randomized Comparison of Antiarrhythmic Therapy vs. Radiofrequency Catheter Ablation (SHAARC)
Paroxysmal or chronic atrial fibrillation (AF) develops in about 20- 25% of adult patients
with hypertrophic cardiomyopathy (HCM) and represents an important complication in the
clinical course of the disease, with adverse long-term consequences on functional status and
outcome.
Therefore, aggressive therapeutic strategies are indicated to restore and maintain sinus
rhythm (SR) in patients with HCM. Nevertheless, pharmacologic prevention of AF recurrence is
challenging because of the limited long-term efficacy and potentially hazardous side effects
of available treatment options. Currently radiofrequency catheter ablation (RFCA) of AF is
successfully used in clinical practice. However, comparison of the efficacy and safety of
these two therapeutic options has not been done up till now in randomized manner in this
group of patients.
Thus, the aim of the present study is to compare the efficacy and safety of RFCA vs.
antiarrhythmic drug therapy in patients with HCM and AF.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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