Atrial Fibrillation Clinical Trial
Official title:
SAAB: Randomized, Double Blind STudy of Corticosteroid Pulse After Ablation
Radiofrequency ablation is an effective treatment for atrial fibrillation. However, about 20%
of the time the atrial fibrillation recurs. Steroids given after the ablation may decrease
inflammation caused by the ablation and thus improve healing and decrease the chance of
recurrence of atrial fibrillation.
In this study patients will be randomized to receive intravenous steroids or not immediately
following the ablation.
Atrial fibrillation, a common arrhythmia, is the source of considerable morbidity. Prevalence
of atrial fibrillation in adults is 0.5%, increasing to 10% in those patients over the age of
seventy five. Numbers are expected to increase nearly 2.5 fold over the next 50 years.
Radiofrequency (RF) ablation to cure atrial fibrillation has become an established and
effective therapy in the many atrial fibrillation patients. However, approximately 20% return
with recurrent atrial fibrillation after ablation.
RF ablation directly targets the substrate for atrial fibrillation, cauterizing cardiac
tissue through the application of radiofrequency energy , causing a myocardial lesion which
effectively blocks the errant pathway. This process of RF ablation induces an inflammatory
effect. As the lesion heals it often enlarges. This may contribute to recurrence of atrial
fibrillation after ablation, as well as increased pain. There is some early evidence that a
single dose of corticosteroids after ablation may improve the healing process, thus
decreasing pain and incidence of recurrent atrial fibrillation.
The aim of the study is to determine the usefulness of a one time dose of solumedrol
following radiofrequency ablation for atrial fibrillation..
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