Atrial Fibrillation Clinical Trial
Official title:
The Effect of Atrial Fibrillation Hemodynamics on Regulation of Cerebral Blood Flow
The proposed research will investigate whether the irregular effects of atrial fibrillation on the body's circulation directly impacts the regulation of cerebral blood flow. To further delineate this finding, investigation of these potential effects will include differences in postural positioning. This data will be used to further understand the overall hemodynamic effects of atrial fibrillation on extra-cardiac organs of the body.
This is a prospective study evaluating 10 subjects referred for elective direct current
cardioversion (DCCV) of atrial fibrillation. Subjects will be seen at Parkland Health and
Hospital System.
After full consent is obtained and explanation of the research, each subject will undergo a
series of entirely non-invasive tests including Transcranial Doppler ultrasound (TCD), manual
cuff blood pressure (BP), beat to beat BP monitoring by a Portapress monitor, and respiratory
tidal CO2. These measurements will be taken after laying the patient in a supine position for
10 minutes and subsequently after standing for 10 minutes. Measurements will also be taken
after full body squat -stand repetition at 20 second intervals (0.05 Hz) x 5 minutes.
Patients who are unable to squat may rise from a seated position on a chair. This protocol
has been easy to follow even for debilitated patients with Alzheimers Disease in Dr. Zhang
and Dr. Levine's laboratory. The subject will then undergo elective DCCV as planned for
standard of care. The above measurements and with respective body positions will then be
repeated 30 minutes later if the patient has been successfully converted to normal sinus
rhythm by DCCV.
The experimental testing will take approximately 1 ½ to 2 hours to complete.
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