Atrial Fibrillation Clinical Trial
Official title:
Medtronic Genetic Arrhythmia Markers for Early Detection
To generate a list of potential genetic markers that correlate with an increased risk of
life-threatening arrhythmias.
To evaluate ECG-based risk markers such as heart rate variability and T-wave Alternans for
their association with arrhythmic events.
The primary objective is to establish the role of genetics in life-threatening arrhythmias
leading to sudden cardiac death (SCD) and the potential utility of genetic markers in risk
stratification of patients to receive an implantable cardiac defibrillator (ICD). The
successful accomplishment of this goal would serve as the basis for future work on a specific
diagnostic test that can be used to assess risks of threatening arrhythmias in order to
quality patients for implantation of an ICD.
- to identify single nucleotide polymorphisms (SNPs) that can be used to identify
individuals in need of an ICD.
The secondary objectives involve more detailed analysis to search for potentially
unidentified genetic markers of risk for SCD.
1. to identify genes associated with SCD susceptibility.
2. to identify risk factors associated with SCD as found in the case report form (CRF).
3. to correlate SNPs with co-morbidities in the subjects as found in the CRF information.
4. to study the association between parameters derived from Holter recordings and
predictors of life-threatening arrhythmias.
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