Impact of Left Atrial Function on Postoperative Atrial Fibrillation

Atrial Fibrillation Clinical Trial

Official title:

Impact Of Velocity Vector Imaging, Tissue Doppler Imaging, Conventional Echocardiography And P Wave Dispertion In Evaluating Post-Operative Atrial Fibrillation After Coronary Bypass Graft Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00646997
• Other study ID #: YT1977/2
• Status: Completed
• Phase: N/A
• First received: March 26, 2008
• Last updated: June 27, 2008
• Start date: March 2008
• Est. completion date: May 2008

Study information

• Verified date: June 2008
• Source: Florence Nightingale Hospital, Istanbul
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ministry of Health; Turkey: Ethics Committee
• Study type: Observational

Clinical Trial Summary

We aimed to demonstrate the impact of left atrial functions which were evaluated by three different echocardiographic modalities , on postoperative atrial fibrillation.

Description:

Postoperative atrial fibrillation after coronary artery bypass greft operation (CABG) is major complication with a prevalence of 10-50%. Although the men mechanism is not known, in recent studies, age and left atrial function have been demonstrated as the most responsible factors. Velocity vector imaging (VVI) is a new modality which may give accurate and detailed information on both left atrial segmental and global function. In this study, our aim was to assess preoperative left atrial function by using three different echocardiographic modalities, VVI, tissue Doppler imaging and conventional echocardiography and evaluate the relation between the left atrial functions and the development of post-operative atrial fibrillation after CABG.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: May 2008
• Est. primary completion date: May 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 30 Years to 80 Years

Eligibility

Inclusion Criteria:

• 1Coronary artery disease evidenced by coronary angiography

• 2Patients with a decision of undergoing elective coronary artery bypass greft operation

• 3Sinus rhythm in electrocardiography

Exclusion Criteria:

• 1Rheumatic valve disease

• 2Having prosthetic valve

• 3CABG accompanied by other cardiac interventions (such as valvular surgery, ASD closure...etc)

• 4Left ventricular l ejection fraction <40%

• 5Mild to moderate mitral stenosis or regurgitation

• 6Having atrial fibrillation or a history of atrial fibrillation attach during the last two weeks.

• 7Congenital heart disease

• 8Chronic liver disease

• 9Chronic renal disease

• 10Malignancy

Study Design

Observational Model: Case-Crossover, Time Perspective: Prospective

Related Conditions & MeSH terms

• Atrial Fibrillation

Locations

Country	Name	City	State
Turkey	TC.Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Florence Nightingale Hospital, Istanbul

Country where clinical trial is conducted

Turkey, 

References & Publications (1)

Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J 3rd, Romson J, Ferguson S, Leung JM. The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery. Am Heart J. 2002 Jan;143(1):181-6. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Velocity vector imaging derived left atrial segmenter function, Tissue doppler derved left atrial segmenter function, conventional analysis of atrial function by 2D and pulsed wave echocardiography.		April 2008	No