Corticosteroids for the Prevention of Atrial Fibrillation After Cardiac Surgery

Atrial Fibrillation Clinical Trial

Official title:

Feasibility of Corticosteroid in the Prevention of Atrial Fibrillation After Cardiac Surgery: A Prospective, Double-Blind Randomized Multicenter Trial

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00442494
• Other study ID #: KUH5204515
• Status: Terminated
• Phase: N/A
• First received: March 1, 2007
• Last updated: November 15, 2012
• Start date: October 2012
• Est. completion date: October 2012

Study information

• Verified date: October 2012
• Source: Kuopio University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Atrial fibrillation is the most common arrhythmia to occur after cardiac surgery. Inflammatory response may be one etiological factor.

We hypothesized that intravenous corticosteroid administration after cardiac surgery prevents AF after cardiac surgery.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 1
• Est. completion date: October 2012
• Est. primary completion date: October 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Patients scheduled to undergo their first on-pump CABG, aortic valve replacement or combined aortic valve replacement and CABG were enrolled.

Exclusion Criteria:

• Previous episodes of AF or flutter

• Uncontrolled diabetes mellitus

• Systemic mycotic infection

• Active tuberculosis

• Cushing's syndrome

• Psychotic mental disorder

• Herpes Simplex keratitis

• Serum creatinine exceeding 200 µg/ml

• Patients were also excluded if they had a history of previous peptic ulcer or thrombophlebitis.

Related Conditions & MeSH terms

• Atrial Fibrillation

Intervention

Drug:
• intravenous hydrocortisone

Locations

Country	Name	City	State
n/a

Sponsors (3)

Lead Sponsor	Collaborator
Kuopio University Hospital	Oulu University Hospital, Tampere University Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Study couldn´t start due to investigator	Study couldn´t start due to investigator	Study couldn´t start due to investigator
Primary	Study couldn´t start due to investigator	Study couldn´t start due to investigator	Study couldn´t start due to investigator
Secondary	Study couldn´t start due to investigator	Study couldn´t start due to investigator	Study couldn´t start due to investigator