Atrial Fibrillation Clinical Trial
Official title:
Linear Anatomically Versus Focal Electrophysiologically Guided Substrate Ablation in Patients With Persistent Atrial Fibrillation
In this randomized study dealing with the ablative treatment of persistent atrial fibrillation, two ablation strategies are compared: a more anatomically guided linear ablation scheme versus an electrophysiological guided focal ablation strategy aiming at the electrical isolating of the pulmonary veins and ablating areas of fragmented intracardiac electrograms thought to maintain atrial fibrillation.
This randomized study deals with two different ablative treatment strategies for persistent
atrial fibrillation: a more anatomically guided linear ablation scheme with encircling of
the ipsilateral pulmonary veins (PV), a left atrial roof line and an anterior line bridging
the anterior mitral anulus to the ostium of the left superior PV versus an
electrophysiological guided focal ablation strategy aiming at isolating, electrically, the
PV and ablating areas of fragmented intracardiac electrograms thought to maintain atrial
fibrillation.
Both ablation approaches contain isolation of the most common source of triggering foci,
i.e., the pulmonary veins and additional modification of the substrate maintaining atrial
fibrillation.
The study endpoint is a combined efficacy/safety analysis. Extensive follow-up with
three-monthly 7 days holter ECG is provided.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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