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Cardioneuroablation vs Pulmonary Vein Isolation in Treatment of Paroxysmal Atrial Fibrillation

Atrial Fibrillation Paroxysmal Clinical Trial

Official title:
Cardioneuroablation of Right Anterior Ganglionated Plexus vs Pulmonary Vein Isolation in Patients With Paroxysmal Atrial Fibrillation and Enhanced Vagal Tone

Clinical Trial Summary

The goal of this study is to compare effectiveness of cardioneuroablation of right anterior ganglionated plexus and pulmonary vein isolation in patients with enhanced vagal tone expressed as deceleration capacity >7.5ms.

Clinical Trial Description

Patients included into the study will be randomized to a group undergoing cardioneuroablation (CNA) of the right anterior ganglionated plexus (RAGP) or pulmonary vein isolation (PVI). In CNA group the location of RAGP will be determined anatomically below the superior vena cava ostium near the superior-septal aspect of the right atrium. Radiofrequency (RF) applications will be delivered and will be continued until heart rate (HR) acceleration >30% is achieved or if the RF time exceeds 120s. In the PVI group point-by-point RF isolation of all pulmonary veins will be performed. Clinical follow-up (FU) will consist of multiple ambulatory visits combined with standard ECG readings and a 7-day Holter recording. During FU visits, a detailed history of any palpitations, episodes of atrial fibrillation (AF), and hospitalizations for cardiac arrhythmias will be collected. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06058468
Study type Interventional
Source St. Joseph's Centre, Poland
Contact Piotr Futyma
Phone +48 533 503 044
Email piotr.futyma@gmail.com
Status Not yet recruiting
Phase N/A
Start date January 2024
Completion date June 2029
View Details
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