Atherosclerosis Clinical Trial
Official title:
Impact of Consumption of Oats in Lipid Profile of Children and Adolescents With Dyslipidemia at the Outpatient Clinic of Reference in Preventive Pediatric Cardiology at the Institute of Cardiology of Rio Grande do Sul
Atherosclerosis is the leading cause of death and disability in adults. However,
investigations suggest that the basic pathology of heart disease as more severe myocardial
infarction which usually reach mainly middle-aged or above, starts from childhood.
Hypercholesterolemia is one of the most important risk factors for atherosclerosis in adults
and children, is associated with early deposition of lipids in the aorta and coronary
arteries.
Among other recommendations for prevention and treatment of heart disease and risk factors,
is the recommendation to encourage the intake of soluble fiber. The oats, a major source of
soluble fiber, has been recognized as a potential component of the diet to lower blood
cholesterol levels, this effect is attributed mainly to the beta-glucan, a type of soluble
fiber present in large quantities in oats. In 1997 the Food and Drug Administration admitted
that the oat bran, oat flakes and oatmeal may have beneficial effects for health with the
recommendation of daily intake of 3g of beta-glucan from oats and a food that brings a claim
for promotion health, must provide, without enrichment, at least 1 gram of beta-glucan per
serving.
The objective of this project will be compared by randomized clinical trial, the impact of
intake of oats, for 8 weeks in the lipid profile of children and adolescents with
dyslipidemia.
Will be included in the study 120 volunteers aged between 5 and 16 years who are in
nutritional monitoring for at least 1 month. The subjects will be randomly divided into 2
groups, with a control group and another intervention will receive 3 tablespoons of soup
filled with oat bran, which corresponds to 3g of beta-glucan, along with breakfast, lunch
and dinner. Patients will be monitored with consultations on the 2nd, 4th and 8th weeks of
treatment. Blood sample will be performed, to obtain the lipid profile of patients, at the
beginning and end of the study. To compare the groups are used Student's t and squared chi.
The alpha of 0.05 is considered critical. The program will be used Statistical Package for
the Social Sciences (SPSS) version 15.0.
It is expected a decrease in serum levels of total cholesterol and LDL-c. Thus, living
habits and healthy alternatives to prevent these risk factors should be done since
childhood, especially in children who already have cholesterol levels of change.
n/a
N/A
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05052918 -
The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes
|
N/A | |
| Recruiting |
NCT04511234 -
Sirolimus Coated Balloon Versus Standard Balloon for SFA and Popliteal Artery Disease
|
N/A | |
| Completed |
NCT05906797 -
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.
|
N/A | |
| Completed |
NCT03273972 -
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
|
N/A | |
| Suspended |
NCT02932176 -
Machine Learning for Handheld Vascular Studies
|
||
| Recruiting |
NCT05158257 -
Clinical Of Plain Balloon Dilatation Combined Stent Versus Endovascular Debulking Combined Drug-coated Balloon to Treat Arteriosclerosis Occlusive Disease of Lower Extremity
|
N/A | |
| Completed |
NCT01212900 -
Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
|
Phase 4 | |
| Completed |
NCT03697382 -
Effect of Daily Steps on Fat Metabolism
|
N/A | |
| Recruiting |
NCT06230406 -
T-Mem GEne in Atherosclerosis
|
||
| Completed |
NCT03654313 -
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
|
Phase 1 | |
| Completed |
NCT00382564 -
Magnetic Resonance Angiography to Diagnose Atherosclerotic Disease
|
N/A | |
| Recruiting |
NCT02894931 -
Effects of Dietary Interventions on Serum and Macrophage Atherogenicity
|
N/A | |
| Not yet recruiting |
NCT02578355 -
National Plaque Registry and Database
|
N/A | |
| Completed |
NCT02998918 -
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
|
N/A | |
| Recruiting |
NCT02265250 -
Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment
|
||
| Completed |
NCT03393377 -
Preventive Arterial Wall Phenotype and Low-dose Fluvastatin/Valsartan Combination
|
N/A | |
| Completed |
NCT02268513 -
Mediators of Atherosclerosis in South Asians Living in America (MASALA) Social Network Study
|
||
| Completed |
NCT02224339 -
New Technologies to Determine Carotid Plaque Vulnerability
|
||
| Not yet recruiting |
NCT01923012 -
Phase II Randomized Placebo-controlled Study With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis
|
Phase 2 | |
| Completed |
NCT02116829 -
Is There Room for Butter in a Healthy Diet?
|
N/A |