Atherosclerosis Clinical Trial
Official title:
Effects of Dietary Plant Stanol Esters of Blood Flow Among Healthy Adult Human Subject. The BLOOD FLOW -Study
Plant stanol esters as part of daily diet can decrease serum level of LDL-cholesterol up to
10%. This decrease diminishes the risk of development of premature atherosclerosis and it´s
complications (e.g., acute myocardial infarction) in adult human subjects.
The purpose of the present study is to evaluate among healthy human subjects (N=100) effects
of plant stanol esters (3 grams/day for 6 months) as part of daily diet in margarine on
arterial endothelial cells, arterial stiffness, autonomic innervation of the arteries,
arterial blood flow and serum fats. The non-invasive arterial measurements (VaSera®,
EndoPat® and WinCRPS®) are performed and blood samples are taken at the beginning and at the
end of the 6-month-long study period. Also questionnaires concerning healthy, and life and
dietary habits are fulfilled. Dietary records (twice for a 3-day-period) are done.
Hypothesis of the study is that a dietary serum cholesterol lowering intervention has
beneficial influence on the early prognostic markers of premature atherosclerosis.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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