Atherosclerosis Clinical Trial
Official title:
Vitamin D and Zinc Levels in Patients Undergoing Ergometry Test
Low vitamin D levels were found to be associated with cardiovascular morbidity and mortality. Low zinc levels are associated with an increased atherosclerotic burden. Therefore we hypothesized that patients with pathological stress test would have low levels of Vitamin D and zinc compared to patients with a normal stress test.
Hypovitaminosis D is generally defined as 25(OH)D levels of < 20ng/ml, while levels of
21-29ng/ml indicate insufficiency and those above 30ng/ml are regarded as sufficient.
The rational behind the observations associating vitamin D deficiency with CVD is that on
the one hand, hypovitaminosis D was found to be associated with traditional risk factors
such as hypertension (HTN),diabetes mellitus (dm),obesity, dyslipidemia and metabolic
syndrome , on the other hand, experimental data demonstrated that vitamin D could affect
cardiac muscle cells directly, control parathyroid (PTH) hormone secretion, regulate the
rennin- angiotensin- aldosterone system and the immune system, all of which could influence
cardiovascular risk.
Epidemiological studies further support this association, demonstrating high prevalence of
hypovitaminosis D among U.S. adults with cardiovascular disease (74%). An association
between low vitamin D levels and increased myocardial infarction risk as well as total
mortality has been also observed.
Low 25hydroxyvitamin D[ 25(OH)D] levels were also independently associated with all cause
and CVD mortality among patients scheduled for coronary catheterization.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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