Effects of PA-1 Transcriptional Regulation on Monocyte Function

Status Terminated

Clinical Trial Summary

Researching genetic differences in people with no prior medical conditions for better understanding of cardiac diseases through genetic research.

Clinical Trial Description

The discovery and subsequent application of small interfering RNA (siRNA) methods to achieve individual gene silencing in mammalian cells is a robust method that is well-described and validated in mammalian cell culture systems. We will apply this technique to achieve post-transcriptional "silencing" of PAI-1 in monocytes obtained from otherwise healthy volunteers, and study the subsequent loss of this gene's function on the migratory capacity of these cells in the proposed in vitro experimental system. This concept has not yet been demonstrated in the literature, and if validated, would be a novel and fundamental description of the role of PAI-1 in human monocyte biology as related to the development of atherosclerosis. ;

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Atherosclerosis

Clinical Trial Details

NCT number	NCT00512369
Study type	Observational
Source	Vanderbilt University
Contact
Status	Terminated
Phase	N/A
Start date	March 2006
Completion date	July 2011

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