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NCT00686452 Clinical Trial

Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools

Asthma Clinical Trial

— proto nage  

Official title:
Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00686452
Other study ID # CER20159
Secondary ID
Status Recruiting
Phase N/A
First received May 26, 2008
Last updated December 18, 2008
Start date March 2007
Est. completion date May 2009

Study information
Verified date May 2008
Source Laval University
Contact Valérie BOUGAULT, PhD
Phone 418-656-8711
Email valerie.bougault@crhl.ulaval.ca
Is FDA regulated No
Health authority Canada: Canadian Institutes of Health Research
Study type Observational

Clinical Trial Summary

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

1. to compare the prevalence of asthma in swimmers and control subjects

2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects

3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date May 2009
Est. primary completion date May 2009
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 14 Years to 35 Years
Eligibility Inclusion Criteria:

- 14 to 35 years old

- To swim at least 10h per week

- For control subjects, non-competitive healthy subjects

Exclusion Criteria:

- any disease that may interfere with the tests for the controls

- Triathletes are excluded

- Smokers

- Obese or with a BMI more than 29

- Former athletes (control group)

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Canada Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval Québec Quebec

Sponsors (1)
Lead Sponsor Collaborator
Laval University

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Asthma and airway hyperreactivity prevalence in swimmers 3 measurements in the year No
Secondary Airway inflammation and remodeling in swimmers 3 measurements in the year and a bronchial biopsy No
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