Asthma Clinical Trial
To determine whether airway inflammation secondary to inhalation of specific allergens and other environmental agents and functional imbalance of the autonomic nervous system played important roles in asthma and chronic bronchitis.
BACKGROUND:
Asthma and chronic bronchitis are among the most common chronic diseases afflicting
middle-aged and elderly adults in the United States, respectively occurring in 4 percent and
5 percent of the population in these age groups. While chronic bronchitis is often caused by
cigarette smoking and asthma often occurs in nonsmokers in association with atopy, the two
conditions may be difficult to differentiate in many middle-aged and older adults and may
share a number of pathophysiologic features including increased airway smooth muscle tone,
increased airway responsiveness to bronchoconstricting stimuli, and bronchial mucus
hypersecretion. The precise mechanisms which produce the alterations of airway function are
not clear. Such functional alterations may be caused by airway inflammation and
abnormalities of the autonomic nervous system; however, there are little population data
available regarding the importance of airway inflammation and disordered neural regulation
in the pathogenesis of airway hyperresponsiveness and mucus hypersecretion. Also, little is
known about potential interactions between airway inflammation and disordered neural
regulation of airway function in the pathogenesis of chronic airways disease. Information on
the relationships may offer insights into the pathophysiologic mechanisms underlying asthma
and chronic bronchitis in adults.
DESIGN NARRATIVE:
The study was cross-sectional and used a subgroup of the Normative Aging Study, a
longitudinal study of aging in men established by the Veterans Administration in 1963. The
study used data normally collected during NAS examinations and included smoking history,
socio-economic status, anthropometry, respiratory symptoms and illnesses, and pulmonary
function. New data were collected on: indices of inflammation as indicated by histamine,
leukotriene, and serotonin in urine; autonomic activity as indicated by urinary
catecholamine excretion and heart rate variation induced by deep breathing; autonomic
responsiveness as measured by pupillary alpha-adrenergic and cholinergic responses.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
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