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Kidney Biomarkers of Acute Kidney Injury in Patients With Knee Arthroplasty — dexpolvi  

Acute Kidney Injury Clinical Trial

Official title:
Kidney Biomarkers of Acute Kidney Injury in Patients With Knee Arthroplasty- a Pilot Study

Clinical Trial Summary

Sensitive renal markers have been studied abundantly in connection with open heart, liver and transplantation surgery; however in major orthopaedic surgery their use is anecdotal. The aim of the present study is to evaluate use of sensitive renal markers, NGAL (Neutrophil gelatinase associated lipocalin ), KIM-1 (Kidney injury molecule- 1), LFABP (liver-type fatty acid-binding protein), and IL-18 (interleukin -18), in patients coming for elective TKA (total knee arthroplasty) as a pilot study before large study concerning acute kidney injury in orthopaedic surgery.

Clinical Trial Description

Acute renal deterioration is a serious adverse event in elective surgery. Serum creatinine based diagnostics of acute kidney injury may delay diagnosis and produce false negative results since serum creatinine is affected by diet, muscle mass, used hydration therapy. In recent times new markers have been developed and tested in order to find sensitive, fast and reliable marker of renal deterioration. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02642731
Study type Observational
Source Kuopio University Hospital
Contact
Status Completed
Phase N/A
Start date September 2013
Completion date December 2015
View Details
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