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Arthritis of Knee clinical trials

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NCT ID: NCT02581605 Active, not recruiting - Arthritis of Knee Clinical Trials

Correction of Angular Deformities in Knee Arthrosis

Start date: November 2014
Phase:
Study type: Observational

For participants whose leg bones don't line up properly, extra stress is placed on either the inner or outer side of the knee joint due to uneven transfer of body-weight. Gradually, this extra pressure wears away the smooth cartilage, resulting in osteoarthritis on that side of the knee joint. This problem is particularly common in young athletes and places them at risk of early osteoarthritis. An operation exists whereby one of the bones either side of the knee is cut ( an osteotomy) and hinged open to straighten the leg. This alteration redistributes body-weight more equally across the knee joint and is known to be effective in delaying and possibly preventing, the progression of knee osteoarthritis- especially in younger and physically more active patients in whom a knee replacement is undesirable. Currently it is possible to ( accurately) calculate the precise position of the bone cut and number of degrees correction required to straighten a leg using digital x-rays and three-dimensional CT scans. However there is no method of implementing this pre-operative plan during surgery so that the majority of surgeons rely on relatively crude and ipso facto unreliable intra-operative measurements as a guide. To improve the accuracy of this operation, the investigator propose the use of a custom-made 'cutting block', tailored for each individual patient and its shape will match the contour of the patient's bone to ensure it can only be placed in one position. Pre-cut slots and holes will then guide the saw cut and the number of degrees the bone in hinged open, as per the pre-operative plan; it functions as an intra-operative template for the surgeon. This study will primarily examine whether there is a close match between the planned and actual correction of leg deformities when using a patient-matched cutting-block.

NCT ID: NCT02294045 Withdrawn - Knee Arthroscopy Clinical Trials

Analysis of Joint Sounds in the Diagnosis of Knee Disorders

Joint
Start date: January 20, 2017
Phase:
Study type: Observational

Clinical-noninvasive recording of sounds from the knees through a brief loaded range of motion. Description in phase 1 analytic but descriptive as well in phase 2. No samples other than a sound recording. The device is known microphone attached to the skin of the knee with elastic material. Sound recorded and analyzed on a lap top computer with Adobe software.

NCT ID: NCT01873313 Completed - Arthritis of Knee Clinical Trials

Blood Levels of Local Anaesthetic in Knee Arthroplasty

BLOCKS
Start date: August 2012
Phase: N/A
Study type: Observational

The primary goal is to evaluate ropivacaine blood concentrations during and after local anaesthetic (ropivacaine) infiltration - the Caledonian technique - for total knee replacement surgery. The investigators plan to measure these levels by testing blood samples taken over a timed period. This will allow us to confirm whether the current regimen of local anaesthetic use is within safe limits.

NCT ID: NCT01586312 Completed - Knee Osteoarthritis Clinical Trials

Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells

MSV_allo
Start date: April 2012
Phase: Phase 1/Phase 2
Study type: Interventional

In this study we want to evaluate the clinical use of allogenic mesenchymal stem cells (MSC), obtained from bone marrow of healthy donors, for treatment of knee osteoarthritis. The trial is based in our own previous results with autologous MSC (ongoing NCT01183728 trial). We propose here a multicenter, phase I-II clinical trial, prospective, randomized, blinded, and controlled for the treatment of osteoarthritis (degrees II and III and IV). The assay consists of two arms with 15 patients each one. Patients in the experimental arm will be given an intra-articular transplantation of allogenic MSC, expanded "Ex Vivo" with our GMP-compliant procedure (MSV, PEI No. 10-134, authorized by the Competent Authority; same as in NCT01183728). In the control arm a standard treatment with intra-articular injection of hyaluronic acid shall be given. We shall follow the evolution of pain, disability, quality of life and quantitative changes in structure and composition of cartilage determined by T2-weighted MRI relaxation (Cartigram) for one year.

NCT ID: NCT01505452 Completed - Arthritis of Knee Clinical Trials

Study of Surgical Technique With Use of Single-radius Prosthesis in Total Knee Replacement

Start date: November 2011
Phase:
Study type: Observational

The purpose of this study is to clinically demonstrate a phenomenon of measurement error that can occur during placement of a specific type of total knee replacement prosthesis (single radius femoral component) using a certain type of surgical technique (flexion/extension gap balancing).

NCT ID: NCT00758901 Terminated - Arthritis of Knee Clinical Trials

ROCC Knee Data Collection

Start date: November 2003
Phase: N/A
Study type: Observational

This observational study intends to collect efficacy and safety data on ROCC Knee system.

NCT ID: NCT00736138 Completed - Arthritis of Knee Clinical Trials

Hyperpronation and Foot Pain

Start date: June 2007
Phase: N/A
Study type: Interventional

Effects of training and pellots