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NCT06151054 Clinical Trial

Relationship Between Aortic Parietal Inflammation on 18F-FDG PET Scan and Arterial Stiffness as a Function of Age

Arterial Stiffness Clinical Trial

— RAIPAo  

Official title:
Relationship Between Aortic Parietal Inflammation on 18F-FDG PET Scan and Arterial Stiffness as a Function of Age

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06151054
Other study ID # 2022PI141
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 30, 2022
Est. completion date December 6, 2022

Study information
Verified date November 2023
Source Central Hospital, Nancy, France
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Show that there is a relationship between arterial stiffness and aortic parietal inflammation and that this relationship is different in the three age groups with aortic parietal inflammation occurring earlier than arterial stiffness.

Description:

In the literature, a relationship has been demonstrated between local inflammation in the aortic wall and increased arterial stiffness. Arterial stiffness is commonly represented by pulse wave velocity (PWV) measured using an applanation tonometer. It would seem that this parietal inflammation precedes arterial stiffness and consequently, arterial hypertension . Arterial stiffness is an important factor of cardiovascular morbidity and mortality and therefore represents a major public health interest in prevention in the face of the continuous aging of our population . This study will consist in studying on a population divided into three age groups, less than 40 years old, 40 to 60 years old and more than 60 years old, the relationship between thoracic aortic parietal inflammation evaluated using the Standard Uptake Value parameters (SUV) and Hounsfield units (HU) measured on 18F-FDG PET/CT scans performed between 09/04/2018 and 11/06/2020 and arterial stiffness parameters. We will seek to show that there is a relationship between arterial stiffness and aortic parietal inflammation and that this relationship is different in the three age groups with aortic parietal inflammation occurring earlier than arterial stiffness.

Recruitment information / eligibility
Status Completed
Enrollment 89
Est. completion date December 6, 2022
Est. primary completion date November 30, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years to 95 Years
Eligibility Inclusion Criteria: - Patients who underwent whole-body 18F-FDG PET/CT included in the PACTEP study - Patient with an assessment of arterial stiffness by applanation tonometer Exclusion Criteria: - patients without an assessment of arterial stiffness by applanation tonometer

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Measure of aortic inflammation
Standard Uptake Value (SUV) measures of aortic wall

Locations
Country Name City State
France CHRU Nancy Vandoeuvre les Nancy cedex

Sponsors (1)
Lead Sponsor Collaborator
Central Hospital, Nancy, France

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary to etablish a relationship inflammation of aortic wall and arterial stiffness Standard Uptake Value 1 day
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