Arterial Stiffness Clinical Trial
Official title:
Use of Impedance Cardiography and Applanation Tonometry for Prediction of the Antihypertensive Effect. Comparison Between an ATII Receptor Antagonist and a Diuretic.
The principal aim of the study is to determine whether the hemodynamic parameters measured
with the two methods -impedance cardiography and applanation tonometry- can be predictive of
the antihypertensive effect of two different classes of drugs, ATII antagonists and
diuretics.
The drugs that will be used in the study are olmesartan and chlorthalidone and the duration
of the study is 12 months.
The other basic aim of the study is to determine whether there is a difference (>6mmHg)
between the two drugs regarding the reduction of the mean 24hour blood pressure and the
effect of them on the hemodynamic parameters.
The hemodynamic parameters that will be measured by applanation tonometry are augmentation
index, central blood pressure and pulse wave velocity.
The hemodynamic parameters that will be measured by impedance cardiography are cardiac index,
thoracic fluid content index, systemic vascular resistance index and others.
The principal aim of the study is to determine whether the hemodynamic parameters measured
with the two methods -impedance cardiography and applanation tonometry- can be predictive of
the antihypertensive effect of two different classes of drugs, ATII antagonists and
diuretics.
The drugs that will be used in the study are olmesartan and chlorthalidone and the duration
of the study is 12 months.
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