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Arterial Disease clinical trials

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NCT ID: NCT05554055 Not yet recruiting - Thrombosis Clinical Trials

Correlation Between LR-ACT and Anti Xa Activity During Endovascular Surgery Procedures. AXAES (Anti Xa vs ACT-LR in Endovascular Surgery)

AXAES
Start date: November 2022
Phase:
Study type: Observational

Activated clotting time (ACT) is currently recommended to monitor high concentrations heparin anticoagulation. ACT-LR was specifically designed to measure the activity of low dose of heparin used during endovascular surgery. The correlation between ACT-LR and Anti Xa activity which is considered as the gold standard seems to be debated. Few studies in literature had shown controversial results. These studies were conducted in patients who underwent open as endovascular surgery. However, the ACT monitoring is not recommended in open surgery. In addition, heparin administration protocols are not described and specific to each centre. In this study investigators want to study the correlation between LR-ACT and anti Xa after introducing a heparin protocol during complex endovascular procedures.

NCT ID: NCT05054764 Recruiting - Clinical trials for Peripheral Arterial Disease

Promus PREMIER Below The Knee Registry

Start date: August 16, 2021
Phase:
Study type: Observational

The Promus Premier below-the-knee (BTK) drug-eluting stent (DES) is specifically designed to improve BTK vessel patency rates using a platinum-chromium alloy based stent that elutes the anti-restenotic drug everolimus to inhibit neo-intimal hyperplasia. Although DES stents are considered standard of care for certain BTK lesions, there is a paucity of data on the use of DES in the contemporary BTK chronic limb threatening ischemia (CLTI) population, especially in Singapore. The aim of the Promus PREMIER BTK registry is to collect one year data of the Boston Scientific Promus PREMIER BTK DES in BTK lesions in CLTI patients.

NCT ID: NCT04651894 Completed - Clinical trials for Frail Elderly Syndrome

Relationship Between Digital Vascular Function Measured by EndoPAT® in elderlY Patients and Arterial Stiffness

ENDY
Start date: May 1, 2018
Phase:
Study type: Observational

Due to the aging of populations worldwide, we observe an increase of age-related diseases and loss of autonomy with consequent personal, social, medical and economic implications. The aging population is a target for geriatric medicine, necessitating the development of specific diagnostic and therapeutic approaches in order to estimate cardio vascular risk in these individuals. It is thought that arterial stiffening and endothelial dysfunction are among the earliest vascular properties altered with the onset of cardiovascular disease. Moreover aging is characterized by progressive fragmentation and break down of the elastic components of the aortic media, which are partially replaced by highly cross-linked collagen leading to stiffening, dilation, and elongation of the aorta . A major underlying mechanism of these modifications is endothelial dysfunction due to high oxidative stress and low-grade inflammation. Reactive hyperemia index (RHI), a key outcome of peripheral arterial tonometry (PAT) has recently become a reliable tool to measure microvascular endothelial function. Some studies have recently demonstrated the interest to measure in elderly patients arterial stiffness parameters in order to prevent loss of autonomy. This cross sectional study aimed at demonstrating the link between arterial stiffness evaluated by pulse wave velocity and endothelial dysfunction evaluated by RHI to implement the tools of cardio vascular risk evaluation in a population of elderly patients referred in a geriatric day hospital.

NCT ID: NCT04511234 Recruiting - Atherosclerosis Clinical Trials

Sirolimus Coated Balloon Versus Standard Balloon for SFA and Popliteal Artery Disease

FUTURE-SFA
Start date: September 8, 2020
Phase: N/A
Study type: Interventional

This study aims to conduct a randomized, double blind, randomised controlled multicentre trial of sirolimus drug coated balloon versus standard percutaneous transluminal angioplasty for the treatment of superficial and popliteal arterial disease.

NCT ID: NCT04428138 Recruiting - Inguinal Hernia Clinical Trials

Inguinal Hernia and Arterial Disease

HEARD
Start date: June 1, 2020
Phase:
Study type: Observational

Inguinal hernias are associated with problems related to the venous system by the linking to extracellular matrix alterations (ECM). On the other hand, arterial diseases (arterial aneurysms, carotid, stenosis, peripheral artery disease) are widespread in the general population and may share others pathological pathways related to ECM impairment. Aim to this study is to evaluate the prevalence of arterial diseases in patients with inguinal hernia.

NCT ID: NCT04359446 Completed - Clinical trials for Cardiovascular Diseases

Laser-excimer Versus High-pressure Dilation to Treat Under-expansion of the Stent

LASER EXPAND
Start date: September 12, 2020
Phase: N/A
Study type: Interventional

The laser-excimer technology could be an essential tool to correct the under-expansion of the stent once it has been implanted unless severe calcification. The laser-excimer technology achieves a greater minimum luminal area when treating an infra-expanded stent, when compared with the results obtained with the simple dilatation at high or very high pressure.

NCT ID: NCT04285411 Completed - Arterial Disease Clinical Trials

Vital USA SpO2 Accuracy Comparison to Arterial Blood CO-Oximetry

Start date: November 4, 2019
Phase: N/A
Study type: Interventional

Clinical Investigation Plan: Vital USA SpO2 Accuracy Comparison to Arterial Blood CO-Oximetry Study ID# PR 2019-353, Version: Rev 1, Date: 15 Oct 2019 Study Dates: November 4-5, 2019

NCT ID: NCT04258046 Recruiting - Arterial Disease Clinical Trials

Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation

Start date: December 1, 2020
Phase: Phase 2
Study type: Interventional

Arteriovenous malformation (AVM) is a congenital vascular anomaly that progresses throughout life and causes complications including tissue destruction due to rapid overgrowth, bleeding, functional deficits, severe deformity and cardiac failure. Unfortunately, traditional managements have transient benefits with more than 90 recurrence rate within a year. Therefore, there is a significant unmet medical need. The purpose of this study is to assess the safety and efficacy of Trametinib in children and adults with Extracranial Arteriovenous Malformation (AVM).

NCT ID: NCT04061798 Active, not recruiting - Surgery Clinical Trials

ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair.

ACTION-1
Start date: March 2, 2020
Phase: Phase 4
Study type: Interventional

Aim of the ACTION-1 study is to determine whether ACT guided heparinization decreases thrombo-embolic complications (TEC) and mortality after elective open AAA surgery, without causing more bleeding complications.

NCT ID: NCT03970538 Active, not recruiting - Clinical trials for Peripheral Arterial Disease

PROMISE II: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

PROMISE
Start date: December 6, 2019
Phase: N/A
Study type: Interventional

The LimFlow System is intended for endovascular, minimally invasive procedures in patients who have a clinical diagnosis of chronic limb-threatening ischemia and who have been determined to have no surgical or endovascular treatment option (i.e., "no option").