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Arrhythmias, Cardiac clinical trials

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NCT ID: NCT04124237 Completed - Long QT Syndrome Clinical Trials

Long Term Monitoring for Risk of Sudden Death

Start date: May 15, 2015
Phase:
Study type: Observational [Patient Registry]

Risk prediction in in inherited heart rhythm conditions that may cause sudden cardiac arrest or death is difficult. Sometimes the risks may be low but the loss of life in an otherwise healthy young individual is catastrophic. Clinicians often treat to the extreme to prevent this and so often those at unknown risk for a serious cardiac event are treated with an implanted cardioverter defibrillator (ICD) to protect against sudden death even though the risk is low or unknown. ICDs them selves are not without adverse events such as needing battery replacements, mechanical complications, inappropriate shocks and body image and self esteem issues for the patient. This study will use an inject able monitor that is less invasive to monitor inherited heart rhythm patients long term to help gather long term heart rhythm data (3 years) on patients with an inherited heart rhythm that will help to detect symptoms of dangerous heart rhythms so that the appropriate care can be provided.

NCT ID: NCT04117763 Completed - Clinical trials for Diabetes Mellitus, Type 2

Effect of Empagliflozin on Ventricular Repolarization.

EMPATHYHEART
Start date: October 4, 2019
Phase: Phase 4
Study type: Interventional

The present project aims to investigate if the empagliflozin has an antiarrhythmic action. Analyzing the T-wave heterogeneity index, a new electrocardiographic risk marker associated with the prediction of cardiovascular risk, in diabetic patients and coronary artery disease, the investigators will verify if empagliflozin is associated with a reduction in electrical instability.

NCT ID: NCT04112433 Completed - Cardiac Arrhythmia Clinical Trials

Novel Cardiac Signal Processing System

Start date: November 12, 2019
Phase:
Study type: Observational

This study is designed to collect parallel intracardiac signal data during pre-defined periods of clinical interest from the PURE EP system and the existing signal recording and mapping systems. The collected signals will then undergo BLINDED, CONTROLLED evaluation by unbiased electrophysiologist reviewer(s) to determine whether the PURE EP signals provides additional or clearer diagnostic information.

NCT ID: NCT04112290 Recruiting - Clinical trials for Hypertrophic Cardiomyopathy

A Prospective Incident Study of Arrhythmias in Hypertrophic Cardiomyopathy

Start date: November 5, 2019
Phase:
Study type: Observational

The purpose of this research study is to understand more about various heart rhythms (electrical problems) in persons with hypertrophic cardiomyopathy with and without sleep apnea.

NCT ID: NCT04092985 Recruiting - Atrial Fibrillation Clinical Trials

Smart Watch iECG for the Detection of Cardiac Arrhythmias

Start date: September 30, 2019
Phase:
Study type: Observational

This study aims to assess the feasibility and reliability of smart watch iECG provided by the Apple Watch/Apple iPhone for the detection of different cardiac arrhythmias. In this study, results from a 12-lead ECG will be set as the gold standard for the arrhythmia diagnosis, and results from the smart watch iECG (Apple watch/Apple iPhone application and Cardiologist's interpretations) as the index tests. The iECG tracings will be recorded simultaneously, starting and ending at the same time as the standard 12-lead ECG, using the built-in sensors of a smart watch (Apple Watch Series 4) with the ECG application.

NCT ID: NCT04076020 Completed - Atrial Fibrillation Clinical Trials

Atrial Fibrillation Health Literacy and Information Technology Trial in Rural Pennsylvania Counties

AFibLITT_R
Start date: January 8, 2020
Phase: N/A
Study type: Interventional

Atrial fibrillation (AF) is a highly prevalent, morbid condition. Anticoagulation to prevent thromboembolic strokes is a foremost priority in AF but adherence is challenging for patients and lapses in anticoagulation are common. Chronic disease self-management (CDSM) is a recognized program to enhance self-efficacy and improve adherence, quality of life, and patient-centered health outcomes. Rural patients with AF experience increased vulnerability to adverse outcomes due to geographic and social isolation, poor health care access, and limited health literacy. This study uses an innovative, scalable CDSM intervention to improve anticoagulation adherence in rural patients with AF.

NCT ID: NCT04075994 Completed - Atrial Fibrillation Clinical Trials

Atrial Fibrillation Health Literacy and Information Technology Trial

AFibLITT
Start date: January 2, 2020
Phase: N/A
Study type: Interventional

Atrial fibrillation (AF) is a common, morbid condition with increasing prevalence. Poor health-related quality of life is common in AF. Patients experience debilitating symptoms and challenging adherence to long-term (possibly lifelong) anticoagulation. The increased risks of stroke, heart failure and mortality associated with AF persist even with optimal treatment. Morbidity in AF is further exacerbated by social factors. Limited health literacy carries challenges of learning a specialized terminology and navigating specialized treatments. In multiple cardiovascular diseases, self-care has demonstrated improvement in self-efficacy, health-related quality of life, symptom burden, and health care utilization - essential components of patient success with AF. Selfcare can provide the critical skills to navigate a challenging chronic disease and improve patient-centered outcomes. Delivery of self-care as a mobile health intervention can complement standard care with a longitudinal intervention to improve patient-centered strategies for AF. While self-care interventions for AF have focused foremost on self-monitoring of anticoagulation,self-care has demonstrated its potential to meet the "triple aim" of improved patient experience, reduced health care utilization, and lower costs.

NCT ID: NCT04053816 Active, not recruiting - Clinical trials for Arrhythmias, Cardiac

Prevention of Dysrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter

TIGHT-K
Start date: October 20, 2020
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether a strategy of maintaining serum potassium levels at ≥3.6 mEq/L is non-inferior to a strategy of usual treatment (≥4.5 mEq/L) on the occurrence of new onset atrial fibrillation after cardiac surgery (AFACS) in patients undergoing isolated coronary artery bypass graft (CABG) surgery.

NCT ID: NCT04041466 Completed - Atrial Fibrillation Clinical Trials

Validation Study of a Watch for the Detection of Atrial Fibrillation

MOVE-ECG
Start date: June 7, 2019
Phase: N/A
Study type: Interventional

The proposed clinical study aims at validating the diagnostic performance, in comparison with a reference ECG, of Withings HWA08 watch for the automatic identification of atrial fibrillation (AF).

NCT ID: NCT04038476 Active, not recruiting - Clinical trials for Conscious Sedation During Procedure

Transcutaneous Carbon-dioxide Monitoring in Electrophysiological Procedures in Deep Sedation

TRACES
Start date: August 20, 2019
Phase: N/A
Study type: Interventional

Complex procedures for treatment of cardiac arrhythmias are usually performed under deep sedation, since a quiet position of the patient is usually required over several hours and a significant risk of injury is caused by unconsciously movements of the patient. The sedative medication inhibits respiration. This can result in an increase of CO2-levels or a reduction oxygen-levels in the blood. Therefore, oxygen saturation (finger clip) is monitored continuously and the CO2-levels in the blood are evaluated every half hour. The study aims to evaluate, whether additional continuous CO2 measurement (transcutaneous CO2 monitoring) has a safety benefit for patients in sedation. Patients are randomly divided into two groups. The first group receives the previous standard monitoring and the second group additionally receives the transcutaneous CO2 measurement. After completion of the procedure, all study-relevant parameters are collected. Finally, the investigators examine whether oxygen saturation decreases or CO2-level increases could be prevented by a continuous, transcutaneous CO2 measurement.