ARDS Clinical Trial
Official title:
Assessment of V/Q Matching During Pressure Support Ventilation With Electrical Impedance Tomography
NCT number | NCT05781802 |
Other study ID # | EIT01 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | February 27, 2023 |
Est. completion date | January 1, 2024 |
The aim of this study is to describe the effects of different levels of pressure support on ventilation-perfusion matching in patients recovering from ARDS, using electrical impedance tomography.
Status | Recruiting |
Enrollment | 15 |
Est. completion date | January 1, 2024 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Age = 18 years - Need for invasive mechanical ventilation and ICU admission - Diagnosis of ARDS at ICU admission or during ICU stay - Informed consent - Presence of central line in the internal jugular vein Exclusion Criteria: - Any contraindication to Electrical impedance tomography monitoring (e. g. severe chest trauma or wounds) - Cardiogenic pulmonary edema - Pulmonary embolism - Chronic obstructive pulmonary disease - Pulmonary fibrosis - Asthma exacerbation - Pneumothorax and/or chest drainages - Pre-existing diaphragmatic function impairment - Neuro-muscular disease or impairment - Moribund patients with limitation of care or expected survival <48h according to the treating physician |
Country | Name | City | State |
---|---|---|---|
Italy | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone. Università degli Studi di Palermo | Palermo |
Lead Sponsor | Collaborator |
---|---|
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo |
Italy,
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Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in ventilation-perfusion matching | Changes in ventilation-perfusion matching between the two different levels of pressure support ("high" level of pressure support and "low" level of pressure support) | Measured after at least 20 minutes from the application of each of the levels of pressure support and at clinical stability | |
Secondary | Changes in gas exchange | Changes in gas exchange measured by blood gas analysis between the two different levels of pressure support ("high" level of pressure support and "low" level of pressure support) | Measured after at least 20 minutes from the application of each of the levels of pressure support and at clinical stability | |
Secondary | Changes in regional ventilation distribution | Changes in regional ventilation distribution between the two different levels of pressure support ("high" level of pressure support and "low" level of pressure support) | Measured after at least 20 minutes from the application of each of the levels of pressure support and at clinical stability | |
Secondary | Changes in regional perfusion distribution | Changes in regional perfusion distribution between the two different levels of pressure support ("high" level of pressure support and "low" level of pressure support) | Measured after at least 20 minutes from the application of each of the levels of pressure support and at clinical stability |
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