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Appendicitis clinical trials

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NCT ID: NCT04163211 Completed - Appendicitis Clinical Trials

Abdominal Drainage During Appendicectomy - Resources Down the Drain: A Retrospective Cohort Study

Start date: March 1, 2018
Phase:
Study type: Observational

The investigators performed a retrospective review of all patients undergoing appendicectomy from March-November 2018 using the online theatre database and discharge letters. CA was defined as patients with perforated or gangrenous appendicitis on histology. Patients were divided into 2 groups; Group 1 (G1) included patients with CA who had a drain inserted; Group 2 (G2) included patients with CA and no drain.

NCT ID: NCT04142203 Completed - Appendicitis Clinical Trials

Implementation of 23 Hour Surgery Model in a Tertiary Hospital

Herko
Start date: May 16, 2017
Phase:
Study type: Observational

Extended day surgery or 23 h surgery (23-hour surgery) is a surgical model where patients arrive to the hospital from home at the day of surgery, are operated and recover in a 23 h surgery unit. 23H surgery units are usually situated near postoperative recovery unit. THe 23 H surgical model was implemented in Kuopio University Hospital 2015 and between May 2017-May 2018 patients were recruited in the present prospective follow up cohort study. Patients were informed and they gave their informed consent. The patients were contacted two weeks after the study and details of their recovery were asked.

NCT ID: NCT04083313 Completed - Clinical trials for Laparoscopic Surgery

Analysis of Endoloops, Endostaples and Endoclips for Closing the Appendiceal Stump During Laparoscopic Appendectomy

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

In this randomized control trial the patients with acute appendicitis will be divided in three groups according to the management of the appendiceal stump(Endostapler, Endoloop or Endoclip). Pre-, peri- and postoperative data will be analysed.

NCT ID: NCT04033211 Completed - Appendicitis Clinical Trials

NOVOsyn® for Trocar Incision After Laparoscopic Appendectomy and Cholecystectomy

NOVOTILAC
Start date: February 13, 2020
Phase:
Study type: Observational

The aim of this study is to evaluate if the application of a Chlorhexidine coated suture (Novosyn® CHD) will reduce the colonization of bacteria in comparison to an uncoated suture (Novosyn®) used for the closure of trocar wounds in laparoscopic surgery (appendectomy and cholecystectomy).

NCT ID: NCT04031196 Completed - Children Clinical Trials

Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Children Undergoing Laparoscopic Appendicectomy

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

QL block has been recently described for chronic pain following abdominal hernia repair, and for postoperative analgesia following abdominal surgery as it leads to complete pain relief in the dermatomal area from (T6 - L1). Theoretically, QL blocks might give better and longer-lasting analgesia compared to the US-guided anterior TAP block due to a spread to the thoracic paravertebral space and sympathetic nerves in the thoracolumbar fascia, so visceral afferent pathways to the medulla can be blocked.

NCT ID: NCT04030741 Completed - Acute Appendicitis Clinical Trials

Non-operative Treatment of Acute Non-perforated Appendicitis

Start date: September 1, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Gold Standard treatment of appendicitis is appendectomy but non-operative treatment of non-perforated appendicitis with antibiotics is also under trial. Although appendectomy is curative but it is an invasive procedure done under general anesthesia with different risks and complications during and after operation, leading to disturbance of child daily routines and activities. Reported rates of perioperative complications are from 5% - 10%, with serious complications occurring in 1% to 7% of patients. Children presenting with acute (<2 days) right iliac fossa pain with pediatric appendicitis score >7, with none of the following on ultrasonography: abscess formation, or loss of the echogenic sub-mucosal layer of the appendix or presence of an appendicolith or periappendiceal fluid collection will be labeled as having appendicitis. After diagnosis we divided the patients into two groups.patients in group A will be treated with antibiotics and appendectomy is done for group B patients.

NCT ID: NCT03988660 Completed - Appendicitis Clinical Trials

The Circulating Fibrocyte - a Novel and Accurate Biomarker in Diagnosing Acute Appendicitis in Adults

Start date: June 10, 2015
Phase:
Study type: Observational [Patient Registry]

Accurate diagnostic biomarkers for acute appendicitis (AA) are lacking. Circulating fibrocytes (CFs) are increased in inflammatory states. It is not known whether they are altered in appendicitis. This study aimed to assess if CF altered in AA, and compared their diagnostic accuracy with white cell count (WCC), C-reactive protein (CRP), neutrophils, lymphocytes, neutrophils-lymphocytes ratio (NLR), monocytes, basophils and eosinophils in diagnosis of AA in patients presenting with right iliac fossa pain (RIFP). 95 consecutive adults were recruited in a cohort based prospective study at University Hospital Limerick, 15 were healthy individuals and 80 were patients with RIFP. Peripheral venous samples were obtained at presentation. Clinical, biochemical and histo-pathological parameters were recorded. CF levels were determined by dual-staining for CD45 and Col-1 using FACS and correlated with histopathological diagnoses. P<0.05 was taken as significant. The study hypothesis is that in patients with suspected appendicitis, CF levels may improve the diagnostics, reduce unnecessary radiation and negative appendicectomy rates.

NCT ID: NCT03985514 Completed - Appendicitis Clinical Trials

Acute Appendicitis: Active Observation With and Without Antibiotics

Start date: May 15, 2018
Phase: Phase 4
Study type: Interventional

This study evaluates if early provision of antibiotics is a superior treatment compared to "traditional wait and see" with regard to symptom relief for suspected acute uncomplicated appendicitis.

NCT ID: NCT03947372 Completed - Pain, Postoperative Clinical Trials

Comparison of Outcomes After Laparoscopic Versus Open Appendectomy in Acute Appendicitis

Start date: February 21, 2015
Phase: N/A
Study type: Interventional

A comparison study was performed between laparoscopic appendectomy and open appendectomy in acute setting in tertiary hospital to access the outcome of postoperative pain and hospital stay. As the popularity of laparoscopic appendectomy has failed in major tertiary hospital due to huge amount of patient load in which open appendectomy was performed.This study was performed to prove that outcome of laparoscopic appendectomy are far better than open appendectomy and to increase the use of laparoscopic surgery in acute settings

NCT ID: NCT03930667 Completed - Clinical trials for Appendicitis, Surgery

Closure of the Appendix Stump in Laparoscopic Appendectomy

Start date: March 25, 2015
Phase: N/A
Study type: Interventional

Aimed to the study evaluate the superiority of intracorporal sutures and Hem-o-lok clips in terms of efficiency.