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Apnea, Obstructive clinical trials

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NCT ID: NCT04950894 Active, not recruiting - Clinical trials for Obstructive Sleep Apnea

Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation

OSPREY
Start date: July 27, 2021
Phase: N/A
Study type: Interventional

Multi-center, open-label, prospective, randomized clinical trial of the aura6000(R) System for the reduction of apnea and hypopneas in adult patients with moderate to severe obstructive sleep apnea who have failed or are unwilling to use positive airway pressure treatment.

NCT ID: NCT04882020 Active, not recruiting - Inflammation Clinical Trials

Inflammation and Neurocognitive Damage Markers in Elderly People With Obstructive Sleep Apnea

Start date: August 21, 2019
Phase:
Study type: Observational

The aging process tends to promote an overall increase in inflammation compromising the immunologic system regulation, sleep/wakefulness pattern, and neurocognitive performance. In elders, there is an increase in repetitive arousals during sleep, secondary to breathing interruption by pharynx collapse, generating a transient reduction in oxygen delivery to the brain known as obstructive sleep apnea. This lack in oxygen supply results in an inflammatory process producing brain damage. Some substances present in the blood seem to be associated to neurocognitive damage, like S100β protein, cortisol, interleukin 1-β,6 and TNF-α. In the other way, a substance called brain-derived neurotrophic factor (BDNF) enhances cognitive function, and memory consolidation improvement.