Effect of Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right-hemisphere on Picture Naming in Chronic Aphasia

Aphasia Clinical Trial

Official title:

The Effect of tDCS Stimulation of Right Inferior Frontal Gyrus on Language Recovery in Speakers With Aphasia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05471570
• Other study ID #: tDCSAphasia
• Status: Completed
• Phase: N/A
• Start date: January 1, 2017
• Est. completion date: December 20, 2017

Study information

• Verified date: November 2022
• Source: The University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

There are two opposing hypotheses, namely the interference and laterality-shift hypotheses, regarding the role of the right hemisphere (RH) in language recovery following a left hemisphere damage. Transcranial direct current stimulation (tDCS) has received increasing attention as a potential complement to behavioural therapy.

This preliminary study aimed to examine the effect of excitatory (anodal) stimulation of right inferior frontal gyrus (IFG) on naming abilities of chronic people with aphasia (PWA) to examine the compensatory versus interference role of RH in language recovery, and to confirm the application of tDCS does not induce adverse effects on other cognitive and language functions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 4
• Est. completion date: December 20, 2017
• Est. primary completion date: November 1, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 90 Years

Eligibility

Inclusion Criteria:

• People with chronic aphasia following the stroke

Exclusion Criteria:

• history of seizure or epilepsy,

• previous adverse reactions to TMS/tDCS,

• having a pace-maker or a metal implanted in the brain

• being pregnant

Related Conditions & MeSH terms

• Aphasia

Intervention

Device:
• tDCS stimulation
The study examines the effect of excitatory stimulation of right inferior frontal gyrus (IFG) on naming abilities of people with aphasia (PWA) as compared to sham stimulation to examine the compensatory versus interference role of right hemisphere in language recovery after stroke.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
The University of Hong Kong

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Picture naming task	One hundred and sixty pictures of concrete nouns from the Snodgrass and Vanderwart (1980) picture set (colored version) were utilised to measure the percentage of object naming accuracy. In particular, these pictures were divided into Set A (training targets) and Set B (untrained generalization targets), with eighty stimuli in each set.	Immediately after the end of each treatment session and block
Secondary	language task	* Overall language skills are measured through the overall aphasia scores provided by the Cantonese version of Western Aphasia Battery (short-form).; The scale is called Aphasia quotient: Minimum value = 0, maximum value = 100, with higher scores mean a better performance.	Immediately after the end of each treatment block
Secondary	Cognitive task	The cognitive skills are measured through the subtest scores provided by Oxford Cognitive Screening-Cantonese. The test uses different sub-tests including the Picture naming, Semantics, Orientation, Visual field task, Sentence reading , Calculation, Attention, Praxis, Memory, and Executive tasks. The range of values varies across the subtests. For all subtests except the executive task, the higher scores reflect better performance. For executive tasks the lower scores reflect better performance.	Immediately after the end of each treatment block