Aphasia Clinical Trial
Official title:
Evaluating the Effects of Intensive Speech and Language Rehabilitation Regarding Neuroplasticity, Speech, Language, Communication Skills and Quality of Life for People With Acquired Aphasia and/or Apraxia of Speech in the Chronic Phase
The present study aims to investigate the short- and long-term effects of two weeks of intensive speech-language pathology intervention with additional physiotherapy, on aphasia and apraxia of speech (AOS) and their neural correlates in thirty persons with chronic stroke. Changes are studied following intensive treatment of aphasia and AOS with standardised speech-language testing and testing of communication and with voxel-based morphometry (VBM) analysis and resting state functional connectivity (rsFC).
Status | Recruiting |
Enrollment | 30 |
Est. completion date | July 31, 2025 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - Aphasia 7 months post stroke diagnosed by SLP - Apraxia of Speech 7 months post stroke diagnosed by SLP Exclusion Criteria: - Dementia - Severe loss of sight - Severe loss of hearing - Metal implants (preventing fMRI) - Claustrophobia (preventing fMRI) |
Country | Name | City | State |
---|---|---|---|
Sweden | Uppsala Universitet | Uppsala |
Lead Sponsor | Collaborator |
---|---|
Karolinska Institutet | University of Malaga |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Comprehensive Aphasia Test (CAT) language battery, in pilot Swedish test A-ning. | Comprehension of spoken language: minimum score 0, maximum score 66; Comprehension of written langugage: minimum score 0, maximum score 62; Repetition: minimum score 0, maximum score 74; Naming: minimum score 0, maximum score no limit; Reading: minimum score 0, maximum score 70; Writing: minimum score 0, maximum score 76. Higher scores mean better outcome in language functions. | Changes from baseline in language battery scores at 2 and 18 weeks. | |
Primary | Rating scale for apraxia of speech (SkaFTA, Swedish version of ASRS) | Minimum score 0, maximum score 52. Lower scores mean better outcome in speech functions. | Changes from baseline scores at 2 and 18 weeks. | |
Primary | Communication Outcome After Stroke (COAST) | Minimum score 0, maximum score 100. Higher scores mean better outcome in communication. | Changes from baseline scores at 2 and 18 weeks. | |
Primary | Goal Attainment Scaling (GAS), International Classification of Functioning, Disability and Health (ICF). Aphasia adapted GAS scales for self-evaluation of communication functions, participation and activity. | Minimum score -2, maximum score +2. Higher scores mean better outcome in quality of life. | Changes from baseline at week 18. | |
Secondary | Barrow Neurological Institute Screening for Higher Cerebral Function (BNIS) | Minimum score 0, maximum score 50. Higher scores mean better outcome in cognition. | Changes from baseline at week 2 | |
Secondary | Boston Naming Test (BNT) | Minimum score 0, maximum score 60. Higher scores mean better outcome in naming ability. | Changes from baseline at week 2 and week 18. | |
Secondary | Protocol for Apraxia of Speech (TAX) | Minimum score 0, maximum score 30. Lower scores mean mean better outcome in speech functions and non verbal oral apraxia. | Changes from baseline at week 2 and week 18. | |
Secondary | Comprehensive Aphasia Test (CAT), subtest cognitive screening | Minimum score 0, maximum score 38. Higher scores mean better outcome in cognitive functions. | Changes from baseline in Comprehensive Aphasia Test cognitive screening scores at 2 and 18 weeks. |
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