Aortic Stenosis Clinical Trial
Official title:
Effect of Steroids on Cerebrospinal Fluid Markers of Inflammation and Neuronal Damage After Surgical Aortic Valve Replacement
The purpose of this study is to investigate if methylprednisolone is effective in reducing the cerebral inflammatory response after open heart surgery with cardiopulmonary bypass.
In a previous study we found that patients undergoing aortic valve surgery had elevated
cerebrospinal inflammatory markers. In this study we aim to investigate if this inflammatory
response can be reduced after treatment with steroids.
30 patients will be randomized to intraoperative treatment with either placebo or
methylprednisolone 15mg/kg. CSF and blood will be collected the day before and the day after
surgery, analyzed for markers of inflammation (IL-6, IL-8), neuronal damage (S-100) and
blood brain barrier function (alb).
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