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Aortic Dissection clinical trials

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NCT ID: NCT03948555 Recruiting - Aortic Dissection Clinical Trials

Magnetic Resonance Imaging (MRI) for Aortic Dissection to Visualise Inflammation

Start date: September 11, 2019
Phase:
Study type: Observational

The study is a single-centre, prospective, observational cross-sectional imaging study aimed to determine if macrophage-mediated inflammation can be visualised in the aorta of patients with aortic dissection (AD) using ultrasmall super paramagnetic iron oxides (USPIO)-enhanced magnetic resonance imaging (MRI).

NCT ID: NCT03894033 Recruiting - Aortic Dissection Clinical Trials

Post-market Registry of the AMDS for the Treatment of Acute DeBakey Type I Dissection

PROTECT
Start date: March 12, 2019
Phase:
Study type: Observational [Patient Registry]

The objective of this registry is to collect information on the performance and clinical benefits of the AMDS (Ascyrus Medical Dissection Stent) to treat patients with acute "DeBakey type I dissections" and with or without so called "preoperative clinically relevant malperfusion" and/or "intramural hematomas". In a healthy aorta (the vessel that supplies blood to most of the body) the blood flows freely through the main lumen (a space inside the vessel where blood flows). The participants involved in this study have a tear that has separated the inner layer of the aorta wall and created a secondary channel (false lumen) in addition to the main channel (true lumen), and huts, the blood flows through both channels. AMDS is a stent (a metal tube helping to keep the vessel open) that is placed in the descending thoracic aorta. AMDS is a medical device commercially available in the countries in which the study is being conducted and it is used as standard of care according to its indication.

NCT ID: NCT03885635 Recruiting - Aortic Dissection Clinical Trials

Hemiarch vs Extended Arch in Type 1 Aortic Dissection

HEADSTART
Start date: May 15, 2019
Phase: N/A
Study type: Interventional

HEADSTART is a prospective, open-label, non-blinded, multicenter, randomized controlled trial that compares a composite of mortality and re-intervention in patients undergoing hemiarch and extended arch repair for acute DeBakey type 1 aortic dissection. Eligible patients will be randomized to one or the other surgical strategy and clinical and imaging outcome data will be collected over a 3 year follow up period.

NCT ID: NCT03824626 Recruiting - Aortic Dissection Clinical Trials

Biomechanical Reappraisal of Planning for Thoracic Endovascular Aortic Repair

MALAN
Start date: May 23, 2019
Phase:
Study type: Observational

Thoracic endovascular aortic repair (TEVAR) for disease involving the aortic arch remains complex and challenging due the angulation and tortuosity of the arch and its peculiar biomechanical environment. Currently, TEVAR planning is based on the analysis of anatomical features by means of static imaging protocols. Such an approach, however, disregards the impact of pulsatile forces that are transmitted as migration forces on the terminal fixation sites of the endograft, and may jeopardize the long-term clinical success of the procedure. Hence,the investigators aim to assess the migration forces acting on different proximal landing zones of the aortic arch by computational modeling, and develop in silico patient-specific simulations that can provide a quantitative evaluation of the stent-graft performance. Study's results are expected to provide valuable insights for proper proximal landing zone and stent-graft selection during TEVAR planning, and ultimately improve postoperative outcome.

NCT ID: NCT03780738 Recruiting - Aortic Dissection Clinical Trials

A Validation Study of The Relationship Between ALDH2 and Aortic Dissection

VaRALAD
Start date: October 1, 2018
Phase:
Study type: Observational

The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.

NCT ID: NCT03707743 Recruiting - Aortic Dissection Clinical Trials

Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)

STABILISE
Start date: October 30, 2018
Phase:
Study type: Observational [Patient Registry]

The aim of the study is to evaluate results of patients treated with the STABILISE technique for acute/subacute aortic dissection. Results and postoperative events are reported in accordance with the current reporting standards for endovascular aortic repair prepared and revised by the Ad Hoc Committee for Standardized Reporting Practices in Vascular Surgery of The Society for Vascular Surgery/American Association for Vascular Surgery

NCT ID: NCT03669055 Recruiting - Aortic Dissection Clinical Trials

Hemodynamic Changes in the Aorta After Endovascular Treatment of the Aortic Dissection

4DAo
Start date: March 7, 2019
Phase: N/A
Study type: Interventional

Aortic dissection (AD) is a serious pathology affecting one person for 300 000 habitants per year. In case of complicated AD on the descending aorta, it is necessary to perform an endovascular surgery in association with medical treatment. An endoprosthesis is implanted on the descending thoracic aorta in order to close the main intimal tear. This closure lead to an increase in the thoracic true lumen diameter, a decrease in the thoracic false lumen diameter, a better perfusion of the aortic branches. Furthermore, even in case of open surgical treatment of the ascending aorta it can be necessary to perform an endovascular treatment on the descending aorta, either to prevent and treat aneurysmal evolution or to treat patent malperfusion syndrome. CT and Magnetic Resonance angiography, by the realization of an aortic morphologic evaluation, are the two key imaging exams in the DA. Nevertheless, CT can't provide aortic dynamic evaluation, contrary to MRI. This exam, thanks to the phase-contrast sequence can measure velocity and flow data in vessels, including aorta but also true and false lumen in the AD. Thus, by verifying the perfusion of the aortic true lumen and the aortic branches it is possible to perform an early evaluation of the endovascular treatment of the DA. Actually, only one study has realized an aortic dynamic evaluation on the AD, unfortunately this study was limited to non-operated patients. In order to assess the place of MRI in the AD, the ingestigation propose to determine if phase-contrast MRI is able to evaluate the impact of the endovascular treatment on the hemodynamic state of the aorta and its branches.

NCT ID: NCT03530748 Recruiting - Aortic Dissection Clinical Trials

On-table Renal Perfusion Evaluation Renal Artery Stenosis or Obstruction

Start date: April 9, 2018
Phase:
Study type: Observational

1. Evaluate the feasibility for the on-table evaluation of the renal perfusion by using Syngo Dyna Parenchymal Blood Volume(PBV) Body; 2. Explore the clinical benefits of this application during procedure to help the physician to determine the procedure endpoint.

NCT ID: NCT03440697 Recruiting - Clinical trials for Aortic Valve Disease

Pathogenetic Basis of Aortopathy and Aortic Valve Disease

TAA
Start date: December 10, 2015
Phase:
Study type: Observational

The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by identifying important genetic modifiers for aortic and aortic valve disease severity.

NCT ID: NCT03347812 Recruiting - Aortic Dissection Clinical Trials

Clinical Study for Evaluating the Safety and Efficacy of Total Endovascular Aortic Arch Repair

Start date: November 22, 2017
Phase: N/A
Study type: Observational

Aortic disease is a kind of cardiovascular diseases with very high mortality rate and high risk of surgical treatment. At present, the surgical and endovascular treatment for diseases in the ascending aorta, descending aorta and abdominal aorta are becoming more and more mature. However, due to the complexity of the aortic arch in anatomy, function and pathological changes, the optimal treatment strategy for diseases in the aortic arch has been controversial constantly. This research is a multi-center(four centers), prospective, controlled, large-scale (about 400 subjects) clinical study, using traditional thoracic surgery of aortic arch disease as a control to verify that new techniques for endovascular treatment is not inferior to traditional thoracic surgery in terms of efficiency and safety. Further more, the investigators plan to explore the indications of the application of these new techniques, develop a better diagnosis and treatment program, reduce the risk of such surgical treatment and the incidence of complications, improve clinical efficacy and the overall quality of the disease.