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Aortic Dissection clinical trials

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NCT ID: NCT04600089 Recruiting - Postoperative Pain Clinical Trials

Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI

2020Ketamine
Start date: December 8, 2020
Phase: Phase 2
Study type: Interventional

The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).

NCT ID: NCT04496687 Recruiting - Clinical trials for Spontaneous Coronary Artery Dissection

International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry

Start date: March 8, 2019
Phase:
Study type: Observational [Patient Registry]

The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD. The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its recurrence. This observational study will be prospective and retrospective in its recruitment and will collect clinical information to better understand the natural history and prognosis for SCAD.

NCT ID: NCT04471909 Recruiting - Aortic Aneurysm Clinical Trials

NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

TRIOMPHE
Start date: October 20, 2020
Phase: N/A
Study type: Interventional

Prospective, non-randomized, multi-center clinical investigation of the NEXUS™ Aortic Arch Stent Graft System (NEXUSTM) for the treatment of thoracic aortic lesions involving the aortic arch with a proximal landing zone, native or previously implanted surgical graft, in the ascending aorta and with a brachiocephalic trunk native landing zone.

NCT ID: NCT04462497 Recruiting - Thoracic Clinical Trials

Chest-Up: Obtaining Safe Positioning for Thoracic Surgery

Start date: July 23, 2020
Phase: N/A
Study type: Interventional

Thoracotomy surgeries, both open and video assisted, are often carried out in the lateral decubitus position to optimize surgical access to the operative side. However, this position is also associated with mechanical injuries of the shoulder joint ligaments and pulling on the structures of the brachial plexus. The neck is laterally flexed and has potential to cause mechanical injury as well due to the dependent position of the patient's head. The current method of positioning involves stacking of towels under a head support. To the study team's knowledge, no pre-formed head and neck support exists that can cope with the required surgical position. Thus, the study team has conceptualized an adaptive head and neck support pillow to meet this need and address patient safety concerns.

NCT ID: NCT04450433 Recruiting - Aortic Dissection Clinical Trials

Functional Study of Metabolites in Patients With Aortic Dissection

Start date: November 1, 2019
Phase:
Study type: Observational

Research on metabolites in patients with aortic dissection, with a view to finding products with high or low metabolism in patients with aortic dissection, looking for metabolic factors related to the onset of aortic dissection, and further verifying the role of metabolic factors in disease through functional verification The role of formation, and ultimately explore the early screening of potential aortic dissection patients

NCT ID: NCT04439565 Recruiting - Aortic Dissection Clinical Trials

Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

Start date: June 17, 2020
Phase:
Study type: Observational

Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.

NCT ID: NCT04304443 Recruiting - Aortic Dissection Clinical Trials

Pre-hospital Management of Aortic Dissection

FFDA
Start date: March 1, 2020
Phase:
Study type: Observational

Background : Time between symptoms onset and treatment initiation is crucial in Acute aortic dissection (AAD). An anti-hypertensive treatment can be rapidly initiated before the arrival in Emergency Department (ED). A better understanding of the chain of care between symptoms onset and surgery could lead to a reduction of morbi-mortality. Our study have the objective to describe the chain of care of patients with AAD in the ED. Methods : This is an observational, retrospective, multicenter study. Patients were detected with a discharge of diagnostic of aortic dissection (ICD I71.0) in university medical center of Besançon. Data collection : patients records in the 8 hospitals centers of the area Franche-Comté.

NCT ID: NCT04251247 Recruiting - Pulmonary Embolism Clinical Trials

Diagnostic Value of D-dimer/Fibrinogen Ratio in Patients With Acute Aortic Dissection

Start date: March 1, 2020
Phase:
Study type: Observational

Acute aortic dissection is rare but potentially life-threatening disease with an incidence of 5-30 cases per million, annually. Therefore prompt diagnosis is crucial. D-dimer values have been shown to be useful in the diagnosis of acute aortic dissection. Fibrinogen levels have been shown to be low, normal or high in individuals with acute aortic dissection. This study aims to investigate whether D-dimer/fibrinogen ratio can be valuable for diagnosis of acute aortic dissection.

NCT ID: NCT04005976 Recruiting - Aortic Aneurysm Clinical Trials

Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

MAC:H-TAD
Start date: April 29, 2016
Phase:
Study type: Observational [Patient Registry]

The Montalcino Aortic Consortium (MAC) will provide the infrastructure to assemble large cohorts of patients with mutations in known heritable thoracic aortic disease (H-TAD) genes, define the phenotype associated with these genes, and determine genetic and environmental modifiers of H-TAD.

NCT ID: NCT03976154 Recruiting - Thoracic Epidural Clinical Trials

Effects of Fixation Technique On Thoracic Epidural Catheter Displacement

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

The purpose of our study is to assess the effectiveness of Dermabond as a thoracic epidural fixation technique compared to both Mastisol and the Grip-Lok fixation bandage, two common, widely used techniques for epidural fixation.