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Antibiotic clinical trials

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NCT ID: NCT06378502 Not yet recruiting - Antibiotic Clinical Trials

The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health

Start date: May 3, 2024
Phase: Phase 4
Study type: Interventional

The aim of the present project (non-inferiority trial) is to evaluate the effect of different antibiotic strategies (long-span vs. short-span) for implant surgery on peri-implant tissue health, oral microbiome (included resistome) and salivary MiRNomics in healthy patients.

NCT ID: NCT05420168 Recruiting - Surgery Clinical Trials

Antibiotic Prescription Relevance Indicators: Calculation From Electronic Health Records

ARIPPA
Start date: January 2, 2021
Phase:
Study type: Observational

This research focuses on the development and validation of indicators on the relevance of antibiotic prescriptions. The investigators want to propose transferable tools to other healthcare institutions to allow automated construction of quality indicators as part of a structured approach to improve future practices. The main objective of the study is to develop indicators on the appropriateness of antibiotic prescriptions and on surgical prophylaxis automated from the hospital information system and to assess their criterion validity.

NCT ID: NCT04976829 Not yet recruiting - Clinical trials for Healthcare Associated Infection

Evaluating Antibiotic Stewardship Assisted by Computer in the University Hospital of Nancy (MACABAO)

MACABAO
Start date: September 1, 2021
Phase:
Study type: Observational

Antibiotic resistance is one of the most pressing health threats that mankind faces now and in the coming decades. Antibiotic resistance leads to longer hospital stays, higher medical costs and increased mortality. In order to tackle antibiotic resistance, a computerized-decision support system (CDSS) facilitating antibiotic stewardship and an electronic surveillance software (ESS) facilitating infection prevention and control activities will implement in our tertiary care university hospital. The investigators conduct a pragmatic, prospective, single-centre, before-after uncontrolled study with an interrupted time-series analysis 12 months before and 12 months after the introduction of the CDSS for antibiotic stewardship (APSS) and ESS for infection surveillance (ZINC). APSS and ZINC will assist respectively the antibiotic stewardship and the infection prevention and control teams of Nancy University Hospital (France). The investigators will evaluate the impact of the CDSS/ESS on the antibiotic use in adult (≥ 18 years) inpatients (hospitalised ≥ 48h). The primary outcome is the prescription rate by all healthcare professionals from the hospital of all systemic antibiotics expressed in defined daily doses/1 000 patients/month. Concurrently, the investigators will assess the safety of the intervention, its impact on the appropriateness of antibiotic prescriptions and on additional precautions (isolation precautions) as recommended in guidelines, and on bacterial epidemiology (multidrug-resistant bacteria and Clostridioides difficile infections) in the hospital. Finally, the investigators will evaluate the users' satisfaction and the cost of this intervention from the hospital perspective.

NCT ID: NCT04546815 Recruiting - Antibiotic Clinical Trials

The Efficacy and Safety of Daptomycin in the Treatment of Gram-positive Bacterial Infection.

Start date: August 25, 2020
Phase:
Study type: Observational

This study aims to collect and analyze clinical data of daptomycin to explore the efficacy and safety of daptomycin in the treatment of Gram-positive bacterial infections. And optimize the dosing regimen based on these data.

NCT ID: NCT04203784 Completed - Sepsis Clinical Trials

Meropenem and Piperacillin Plasma Concentrations During CRRT

ABC2
Start date: November 1, 2012
Phase:
Study type: Observational

This observational study reports meropenem and piperacillin plasma concentrations in patients treated with either antibiotic and simultaneous continuous renal replacement therapy (CRRT).

NCT ID: NCT04146142 Completed - Prostate Biopsy Clinical Trials

Transperineal MRI-TRUS Fusion Guided Prostate Biopsy With vs Without Antibiotic Prophylaxis

NORAPP
Start date: November 11, 2019
Phase: N/A
Study type: Interventional

Prostate biopsy is indicated in patients with suspected prostate cancer and has been traditionally performed through the rectum using antibiotic prophylaxis. Increasing antibiotic resistance of intestinal bacteria is causing a growing number of patients to get post-biopsy infections. Sepsis rate after transrectal biopsies is approximately 4-10%. To reduce the risk of post-biopsy infections, transperineal approach in general anesthesia and antibiotic prophylaxis has been used. The investigators at Oslo University Hospital Aker developed MRI -TURS elastic image fusion guided transperineal prostate biopsy technique in local anesthesia and Bactrim prophylaxis as outpatient procedure. The investigators found 0.4% post-biopsy infection rate. Afterwards a pilot study using the same biopsy technique however without antibiotic prophylaxis was realized in 90 patients. None of these subjects experienced infection. The investigators wish to perform a prospective randomized trial of antibiotic prophylaxis versus none before transperineal MRI-TRUS fusion guided prostate biopsy in local anesthesia in outpatient clinic.

NCT ID: NCT03897582 Recruiting - Pneumonia Clinical Trials

Beta-Lactams Dosing In Pneumonia in ICU in Patients Treated by Continuous Renal Replacement Therapy: the BLIPIC Study

BLIPIC
Start date: February 22, 2019
Phase:
Study type: Observational

Pneumonia are the most frequent infections in ICU. Little is known about beta-lactam doses necessary for this infection for patients treated with continuous veino-veinous hemodialysis. The pharmacokinetic variability expose to over and underdosage leading to toxicity or therapeutic failure. The aim of this study is to define if beta-lactams doses used in pneumonia for patients with acute kidney injury treated with our hemodialysis conditions lead to beta-lactam therapeutic plasma levels.

NCT ID: NCT03583749 Recruiting - Older People Clinical Trials

Pharmacokinetics and Safety of Antimicrobial Agents Administered by Subcutaneous Route in Patients AGEd Over 65 Years

PhASAge
Start date: August 7, 2019
Phase:
Study type: Observational

Elderly people are more prone to develop infection with a poorer prognosis compared to young people. Physicians may encounter difficulties regarding antimicrobial agents administration route. In fact, poor venous access and behavioral disturbance are frequent issues. The subcutaneous (SC) route may be a safe alternative, but sparse data are available in the literature. The present study aims to describe Pharmacokinetics (PK) / Pharmacodynamics (PD) characteristics of antibiotics (amoxicillin/clavulanate, ceftriaxone and piperacillin/tazobactam) subcutaneous administration in patients aged over 65.

NCT ID: NCT03563586 Recruiting - Colorectal Cancer Clinical Trials

Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery

MECCA
Start date: April 1, 2018
Phase: N/A
Study type: Interventional

Investigation of the role of adding oral antibiotics to preoperative mechanical bowel preparation before colorectal surgery for cancer.

NCT ID: NCT03408457 Completed - Clinical trials for Surgical Wound Infection

Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections

Start date: March 14, 2018
Phase:
Study type: Observational

This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.