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Antibiotic clinical trials

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NCT ID: NCT04203784 Completed - Sepsis Clinical Trials

Meropenem and Piperacillin Plasma Concentrations During CRRT

ABC2
Start date: November 1, 2012
Phase:
Study type: Observational

This observational study reports meropenem and piperacillin plasma concentrations in patients treated with either antibiotic and simultaneous continuous renal replacement therapy (CRRT).

NCT ID: NCT04146142 Completed - Prostate Biopsy Clinical Trials

Transperineal MRI-TRUS Fusion Guided Prostate Biopsy With vs Without Antibiotic Prophylaxis

NORAPP
Start date: November 11, 2019
Phase: N/A
Study type: Interventional

Prostate biopsy is indicated in patients with suspected prostate cancer and has been traditionally performed through the rectum using antibiotic prophylaxis. Increasing antibiotic resistance of intestinal bacteria is causing a growing number of patients to get post-biopsy infections. Sepsis rate after transrectal biopsies is approximately 4-10%. To reduce the risk of post-biopsy infections, transperineal approach in general anesthesia and antibiotic prophylaxis has been used. The investigators at Oslo University Hospital Aker developed MRI -TURS elastic image fusion guided transperineal prostate biopsy technique in local anesthesia and Bactrim prophylaxis as outpatient procedure. The investigators found 0.4% post-biopsy infection rate. Afterwards a pilot study using the same biopsy technique however without antibiotic prophylaxis was realized in 90 patients. None of these subjects experienced infection. The investigators wish to perform a prospective randomized trial of antibiotic prophylaxis versus none before transperineal MRI-TRUS fusion guided prostate biopsy in local anesthesia in outpatient clinic.

NCT ID: NCT03408457 Completed - Clinical trials for Surgical Wound Infection

Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections

Start date: March 14, 2018
Phase:
Study type: Observational

This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.

NCT ID: NCT03405168 Completed - Clinical trials for Advanced Breast Cancer

Routine Therapy Plus Moxifloxacin in Advanced Breast Cancer

Start date: January 1, 2018
Phase: Phase 2
Study type: Interventional

This is a phase II,single center,prospective, single arm clinical trial. The objective is to evaluate the efficacy and safety of routine therapy plus moxifloxacin in Advanced Breast Cancer whose evaluation is stable disease with a trend of progression.

NCT ID: NCT03085459 Completed - Septic Shock Clinical Trials

Effects of Nursing Staff on Empiric Antibiotic in Septic Shock

Start date: January 12, 2015
Phase: N/A
Study type: Observational

A retrospective, observational study was performed about the patients with septic shock who admitted into intensive care unit (ICU) from January 1, 2015 to February 29, 2016. The number of patients who received empiric antibiotic treatment within first hour after septic shock diagnosis were collected. Detailed information about clinical ladder for nursing stuff and nursing shift were collected . Clinical ladder for nursing stuff is a new definition based on education background and work experience and nurses stuff are classified into four levels. N0 was defined who got college degree or above, nurse qualification certificate and working time less than one year. N1 an N2 were defined as who got nurse qualification certificate and working time between 1~3 years and more than three years, respectively. N3 was defined who was nurse-in-charge qualification or got nurse practitioner qualification for more than five years. Compliance of empiric antibiotic treatment within first hour and evaluate the effect of nursing stuff on the compliance were calculated.