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Potential Predictive Biological Markers of Major Depression Response to Citalopram Therapy in Anorexia Nervosa. — ANCITA  

Anorexia Nervosa Clinical Trial

Official title:
Potential Predictive Biological Markers of Major Depression Response to Citalopram Therapy in Patients With Anorexia Nervosa: a Single-center Study.

Clinical Trial Summary

In patients suffering from anorexia nervosa associated with severe major depression, serotonin reuptake inhibitor drugs have shown little efficacy in significantly reducing depressive symptoms. A possible explanation for this poor efficacy could be that people with anorexia nervosa have a deficiency in amino acids such as tryptophan, which is necessary for the production of the neurotransmitter serotonin. Therefore, tryptophan supplementation has been suggested as a means of increasing the pharmacological response to serotonin reuptake inhibitor drugs in patients with anorexia nervosa. Furthermore, malnutrition present in patients suffering from anorexia nervosa is in some cases associated with problems of intestinal absorption of nutrients, with possible implications on the pharmacokinetics of the drugs administered, including selective serotonin reuptake inhibitors (SSRIs). The present observational study aims to evaluate the correlations between the clinical response to Citalopram therapy (in different o.s. and i.v. formulations) and some nutritional, neurotransmitter and inflammatory biomarkers, in order to identify potential predictive markers of response to therapy for severe major depression in patients with anorexia nervosa. The following parameters will be evaluated in patients enrolled in all 3 observation times described above: - Plasma concentration of Citalopram - Serum concentration of Serotonin - Plasma concentration of dopamine - Serum concentration of Tryptophan - Serum concentration of BDNF - Hamilton scale 17 items and other clinical scales (EDI-3, SCL-90, BUT).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05795283
Study type Observational
Source Istituto Auxologico Italiano
Contact Riccardo Cremascoli, MD
Phone +393497292068
Email r.cremascoli@auxologico.it
Status Recruiting
Phase
Start date August 1, 2022
Completion date August 1, 2024
View Details
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