Injections of SVF in Ankle Osteoarthritis

Status Active, not recruiting

Clinical Trial Summary

The aim of this pilot study is to analyze the effect of SVF injection produced by adipose tissue processing, in terms of clinical improvement, in patients with moderate to severe (stage 1-3) ankle osteoarthritis. Evaluation will be performed by administering pre-operative and post-operative clinical assessment questionnaires. Patients will be followed-up with a pre-operative evaluation and post-operative evaluations at 30 days, 3-6-12, and 24 months after application.

Clinical Trial Description

30 patients with moderate to severe ankle osteoarthritis (grade 1-3 according to Giannini's classification) will be included in this pilot study, in which patients will be treated with single injection of Stromal Vascular Fraction - SVF ,obtained by processing the patient's abdominal adipose tissue. All patients will be examined with a baseline clinical visit. For obtaining SVF, will be carried out a routinely performed procedure aimed at obtaining a small amount of adipose tissue from all patients. Subsequently, patients will be followed up with clinical evaluation at 1, 3, 6, 12 and 24 months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04998162
Study type	Interventional
Source	Istituto Ortopedico Rizzoli
Contact
Status	Active, not recruiting
Phase	N/A
Start date	May 12, 2022
Completion date	October 31, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02508233` - Cross-cultural Adaptation and Validation of the Ankle Osteoarthritis Scale (AOS) for Use in French-speaking Populations	N/A
Completed	`NCT01504438` - Prospective Randomized Evaluation of a Two and Three Piece Total Ankle Replacement	N/A
Active, not recruiting	`NCT03440008` - Improving the Detection, Classification and Treatment of Misaligned Arthritic Ankles
Active, not recruiting	`NCT06404801` - Development of Stance Control Orthotic Knee Joint For Improvement of KAFO Users
Active, not recruiting	`NCT04405297` - A Disease-based Treatment Study for Diagnosed Osteoarthritis Utilizing Adipose-derived Regenerative Cells
Completed	`NCT01760577` - Effects of Intraarticular Botulinum Toxin A in Ankle Osteoarthritis	N/A
Completed	`NCT03356951` - Gait Analysis Following Total Ankle Replacement and Subtalar Fusion	N/A
Completed	`NCT02489188` - Gait Asymmetry Assessed Using Portable Gait Analysis System
Completed	`NCT01986244` - Total Ankle Replacement for Ankle Arthritis
Withdrawn	`NCT05562154` - Lateral Approach Versus Anterior Approach in Total Ankle Replacement	N/A
Completed	`NCT03567187` - Cryoneurolysis for Improvements in Pain, ADL and QOL in Patients With Ankle Osteoarthritis	N/A
Completed	`NCT05868759` - Assessment of Preoperative and Postoperative Ankle Kinematics	N/A
Recruiting	`NCT06193057` - Comparison of Customized and Standard Total Ankle Prostheses	N/A
Recruiting	`NCT06028763` - Development of Biomedical Technology for the Treatment of Ankle Cartilage Using Injectable Biocomposite Hydrogel	N/A
Completed	`NCT04022928` - A Single Intraarticular Injection of Platelet-Rich Plasma on Pain and Physical Function in Patients With Ankle OA	N/A
Not yet recruiting	`NCT03573245` - Tranexamic Acid in Major Orthopedic Surgery: Comparison of 3 Dosage Regimen
Completed	`NCT02629731` - Orthotic Dose Response Study	N/A
Recruiting	`NCT03157141` - Ankle Osteoarthritis	N/A
Active, not recruiting	`NCT03524729` - Do Rocker Bottom Shoes and Ankle-Foot Orthoses Reduce Pain and Improve Mobility for Ankle Osteoarthritis Patients	N/A
Completed	`NCT03711747` - Indications for Osteochondral Allograft Transplantation