Clinical Trials Logo

Clinical Trial Summary

The heterogeneity of depression suggests that different neurocircuits and pathophysiological mechanisms are involved. Anhedonia - the inability to experience pleasure from, or the lack of motivation to carry out, usually enjoyable activities - is an endophenotype within the depression spectrum, with a distinct pathophysiology of dopaminergic mesolimbic projections. Anhedonia is common in depression and associated with treatment resistance. Pramipexole, an agonist to the dopamine -receptor 3, is an established treatment of Parkinson's disease. Based on its mechanism of action, pramipexole might be efficacious in a subtype of depression characterized by anhedonia and lack of motivation - symptoms linked to dopaminergic hypofunction. In this proof-of-concept pilot study the investigators test the anti-anhedonic and antidepressant effects of add-on pramipexole using an "enriched population study design" including only depressed patients with significant anhedonia. To understand the neurobiology of anhedonia in depression and to identify treatment predictors, the investigators also do assessments of anhedonia-related neurocircuitry using (f)MRI and blood biomarkers.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04121091
Study type Interventional
Source Region Skane
Contact
Status Completed
Phase Phase 2
Start date October 4, 2019
Completion date March 18, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT05234476 - Behavioral Activation Plus Savoring for University Students N/A
Enrolling by invitation NCT06035562 - Promoting Positive Emotional Functioning in Police and Military Populations N/A
Completed NCT02905604 - Magnetic Stimulation of the Brain in Schizophrenia or Depression N/A
Completed NCT03043560 - Study to Treat Major Depressive Disorder With a New Medication Phase 2
Withdrawn NCT05507385 - Imagine a Brighter Future: An Intervention to Improve Positive Emotions in Young People N/A
Completed NCT05383248 - Computational Cognitive Training To Boost Reward Responsiveness In Anhedonic Patients N/A
Suspended NCT03715400 - Mobile Virtual Positive Experiences for Anhedonia N/A
Recruiting NCT05240352 - Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression N/A
Recruiting NCT03915613 - Brain Insulin Resistance in Mood Disorders Phase 1/Phase 2
Completed NCT03939676 - Evaluating Motivation and Reward Mechanisms and Brain Substrates in Adults With Obesity
Enrolling by invitation NCT06285474 - Investigating LIFUP in Anhedonic Depression N/A
Recruiting NCT05870501 - Synaptic Imaging and Network Activity in Treatment Resistant Depression N/A
Active, not recruiting NCT03848715 - Sleep and Healthy Aging Research on Depression for Younger Women Phase 1
Completed NCT05165394 - Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDD Phase 2
Completed NCT04647019 - The Effects of Wild Blueberries on Depressive Symptoms in Young Adults N/A
Recruiting NCT06075771 - Dopaminergic Therapy for Anhedonia - 2 Phase 4
Completed NCT02958228 - The Effect of Computerized Cognitive Training on Mood and Thinking Style Amongst Patients in Inpatient Settings N/A
Recruiting NCT05991713 - Geolocation Positional System (GPS) Experience N/A
Completed NCT05084924 - Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia N/A
Recruiting NCT05988138 - Prevention of Anhedonia in Children N/A