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Angina clinical trials

View clinical trials related to Angina.

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NCT ID: NCT00774891 Withdrawn - Ischemia Clinical Trials

Comparison Of Left Ventricular Volume And Wall Stress With Dobutamine And Exercise Echocardiography

Start date: October 2008
Phase: N/A
Study type: Observational

This study will compare the physiologic responses between exercise stress echocardiography and pharmacologic stress echocardiography on left ventricular volume and wall stress.

NCT ID: NCT00763035 Terminated - Asthma Clinical Trials

Comparison of Dobutamine and Regadenoson Stress Cardiac Magnetic Resonance (MR)

Start date: January 2009
Phase: Early Phase 1
Study type: Interventional

The goal of this research is to determine the utility of Regadenoson (Lexiscan)for use as an imaging agent with cardiac MR. If found useful, it will help us establish a protocol for regadenoson stress MR perfusion (Regadenoson stress test with cardiac MR).The investigators will compare regadenoson with dobutamine so each participant will undergo two studies. A cardiac MR stress test with regadenoson and with dobutamine. The investigators participants will include patients with history of COPD and Asthma, so it will also help us determine feasibility of Regadenoson in these patient's subgroups.

NCT ID: NCT00657514 Withdrawn - Clinical trials for Peripheral Arterial Disease

Ranolazine Versus Placebo Effects on Exercise Tolerance in Patients With Heart Disease and Peripheral Arterial Disease

Start date: May 2008
Phase: Phase 4
Study type: Interventional

After 6 weeks of maximal Ranolazine therapy, tissue hemoglobin desaturation kinetics will change compared to placebo in patients with chronic angina and peripheral arterial disease.

NCT ID: NCT00491218 Recruiting - Angina Clinical Trials

The Addition of Cardiac CT to Exercise Treadmill Testing in the Evaluation of Angina

CT-EXTRA
Start date: June 2007
Phase: N/A
Study type: Observational

The current outpatient evaluation for angina in low and intermediate risk patients typically starts with a functional assessment for coronary ischemia. Exercise treadmill testing is often selected as the initial diagnostic modality for coronary artery function. However, exercise treadmill testing is limited by its moderate sensitivity and specificity, often resulting in further cardiac resource utilization for patient risk stratification and reassurance. With the advent of coronary multislice computed tomography (MSCT) angiography, coronary artery anatomy can now be evaluated noninvasively. Despite its impressive performance characteristics, the role of coronary MSCT angiography in the outpatient evaluation of angina remains undefined. CT-EXTRA compares the impact on patient safety and downstream resource utilization of a novel initial diagnostic strategy employing the addition of coronary MSCT angiography to exercise treadmill testing with a standard diagnostic strategy of exercise treadmill testing for the ambulatory evaluation of low-intermediate risk patients with possible angina. The study is a single center, prospective, non-blinded, randomized clinical trial. Men and women, age 18-70, with a low to intermediate pretest probability of coronary artery disease who are referred for an exercise treadmill test for angina are eligible. Subjects are randomized either to an initial diagnostic strategy of exercise treadmill testing or exercise treadmill testing with coronary MSCT angiography. Subsequent diagnostic testing and treatment are the discretion of the referring physician. Subjects will be clinically followed for 24 months. The clinical impact on patient safety and downstream clinical resource utilization of this novel diagnostic strategy in which both coronary artery anatomy and function are initially evaluated will be determined. The primary outcome is a composite endpoint consisting of freedom from adverse cardiac events, further cardiac diagnostic testing, and future cardiac clinical encounters. Secondary outcomes include the impact on the indiscriminate use of coronary angiography, subject anxiety, depression, motivation for healthy behavioral change, and satisfaction with diagnostic evaluation and use of antiplatelet and antilipid therapy. Lastly, the cost effectiveness of the routine addition of coronary MSCT angiography in the outpatient evaluation of possible angina will be determined.

NCT ID: NCT00351260 Completed - Stenosis Clinical Trials

BBC ONE - British Bifurcation Coronary Study

BBC ONE
Start date: January 2005
Phase: Phase 3
Study type: Interventional

The study aims to assess whether a SIMPLE or a COMPLEX strategy is best for the treatment of coronary bifurcation stenoses.

NCT ID: NCT00221182 Terminated - Clinical trials for Coronary Artery Disease

Stem Cell Study for Patients With Heart Disease

Start date: September 2005
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine if stem cell therapy with your own cells (autologous cells) delivered with a catheter to regions of the heart with poor blood flow will be safe and if it will relieve your chest pain, increase the blood flow, and/or improve the cardiac contractility (function) by regenerating blood vessels in your heart.

NCT ID: NCT00218985 Completed - Clinical trials for Coronary Artery Disease

Exercise-training Before Coronary Artery Bypass Graft (CABG)

Start date: January 2005
Phase: N/A
Study type: Interventional

The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

NCT ID: NCT00159718 Completed - Angina Clinical Trials

Double Blind Atorvastatin Amlodipine Study

DUAAL
Start date: July 2001
Phase: Phase 4
Study type: Interventional

To evaluate and compare the safety and efficacy of amlodipine, atorvastatin and the combination in patients with symptomatic myocardial ischemia. Amlodipine's use in angina has been well documented in clinical trials such as the Circadian Anti-Ischemia Program in Europe (CAPE), but the impact on vascular inflammation in clinical practice has not been tested. Furthermore, the potentially synergistic benefit of atorvastatin and amlodipine on inflammation ischemic activity has not been studied.

NCT ID: NCT00091429 Completed - Angina Clinical Trials

Ranolazine SR in Patients With Chronic Angina Who Remain Symptomatic Despite Maximal Treatment With Amlodipine

Start date: August 2004
Phase: Phase 3
Study type: Interventional

The study will be a multi-national, double-blind, randomized, placebo-controlled, parallel group study to evaluate the effectiveness of ranolazine (1000 mg twice daily) in approximately 500 patients with chronic angina who remain symptomatic despite daily treatment with the maximum labeled dose of amlodipine (10 mg daily), a calcium channel blocker approved for the treatment of chronic angina. Eligible patients will be randomized to receive ranolazine 1000 mg or placebo twice daily, in addition to a daily dose of 10 mg of amlodipine. Participation in the study will last approximately 3 months.

NCT ID: NCT00081913 Completed - Myocardial Ischemia Clinical Trials

Stem Cell Study for Patients With Heart Disease

Start date: January 2004
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine if cell therapy with your own cells (autologous cells) delivered with a catheter to regions of the heart with poor blood flow will be safe and if it will relieve your chest pain and/or your ability to exercise.