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NCT03778944 Clinical Trial

Enhancing Renal Graft Function During Donor Anesthesia

Anesthesia Clinical Trial

Official title:
Renal Graft Functional Enhancement During Donor Anesthesia: A Comparative Study of 3 Modalities

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03778944
Other study ID # RGFEDDA
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date December 20, 2018
Est. completion date July 2024

Study information
Verified date February 2024
Source Cairo University
Contact Nazmy E Seif, MD
Phone 01227400808
Email drnazmyseif@yahoo.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess & compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.

Recruitment information / eligibility
Status Recruiting
Enrollment 60
Est. completion date July 2024
Est. primary completion date July 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - end-stage renal disease, for living-donor kidney transplantation Exclusion Criteria: - severe cardiac or hepatic dysfunction - coagulopathy

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Mannitol infusion
Infusion of Mannitol 20% at a dose of 0.5 mg/kg to the renal graft donor after induction of anesthesia over 15 minutes.
• Dopamine infusion
Infusion of Dopamine at a dose of 4 microg/kg/min to the renal graft donor after induction of anesthesia till ligation of the renal artery.
• Adequate hydration
Infusion of Ringer Acetate at a rate of 15 ml/kg/hr to the renal graft donor after induction of anesthesia till ligation of the renal artery.

Locations
Country Name City State
Egypt Kasr Al-Ainy Hospital, Cairo University Cairo

Sponsors (1)
Lead Sponsor Collaborator
Nazmy Edward Seif

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Post-operative creatinine clearance Post-operative creatinine clearance level of the transplanted kidney graft is measured in ml/min 7 days
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