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Anesthesia, Spinal clinical trials

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NCT ID: NCT06357637 Recruiting - Cesarean Section Clinical Trials

Abdominal Circumference Measure in Caesarian Section

ACirCuS
Start date: December 1, 2023
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to evaluate preoperative measures of abdominal circumference in patients admitted for a cesarean section. The main questions it aims to answer are: - Can preoperative abdominal circumference predict patients with difficult spinal anesthesia - Can preoperative abdominal circumference predict the occurrence of maternal hypotension during cesarean section Participants will be examined preoperatively in terms of visibility and palpation of spinous processes, abdominal circumference will be measured in the supine and sitting positions with other clinical parameters. Spinal anesthesia will be performed by the same experienced anesthesiologist with a standardized procedure. The number of skin punctures, needle reorientations, traumatic Cerebrospinal fluid, need for a paramedian approach or failure will be recorded. Maternal blood pressure and vasopressor requirements will also be monitored.

NCT ID: NCT06343259 Not yet recruiting - Anesthesia, General Clinical Trials

The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery. Cardiovascular events are a leading cause of mortality and morbidity following non-cardiac surgery, with myocardial injury after non-cardiac surgery (MINS) being a significant concern. MINS, characterized by asymptomatic elevation of troponin levels without accompanying ECG findings, is closely associated with postoperative mortality. With the increasing prevalence of comorbidities in the elderly population and the rising frequency of non-cardiac surgeries in this demographic, understanding the effects of different anesthesia types on postoperative myocardial injury is crucial.

NCT ID: NCT06291727 Recruiting - Clinical trials for Arthroplasty, Replacement, Knee

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

Start date: February 16, 2024
Phase: Phase 4
Study type: Interventional

This study is a prospective, double-blind prospective randomized controlled trial comparing mepivacaine and bupivacaine spinal anesthesia for same-day discharge readiness following a unilateral primary elective TKA procedure. Study data will be collected during the patient's hospital stay for their TKA procedure, and the primary outcome of same-day discharge readiness will be assessed the day of surgery. Patients will also be contacted at Day 3 post-op to assess for any complications, current level of pain, and pain medication utilization.

NCT ID: NCT05896631 Not yet recruiting - Anesthesia, Spinal Clinical Trials

The Effect of Spinal Anesthesia on Hemodynamics

Start date: June 8, 2023
Phase: N/A
Study type: Interventional

In this study, it was planned to provide more stable hemodynamics in geriatric patients with low-dose spinal anesthesia. We will compare 7.5mg hyperbaric bupivacaine with 5mg hyperbaric bupivacaine. The researchers hypothesized that low-dose bupivacaine would provide adequate anesthesia, less hypotension, and faster recovery.

NCT ID: NCT05892913 Completed - Pregnancy Clinical Trials

The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients

Start date: July 19, 2023
Phase: Phase 4
Study type: Interventional

The most common side effect in cesarean section surgeries performed under spinal anesthesia is hypotension, which is seen in over 80% and can cause significant morbidity for the mother and fetus. This side effect results from the sympathetic blocking effect, which also causes bradycardia. A combined approach is supported in the prevention and treatment of hypotension, which recommends adequate fluid support, low-dose spinal anesthesia, and appropriate vasopressor (such as ephedrine, and phenylephrine) and, if bradycardia develops, the use of atropine as a parasympatholytic agent. In this study, the investigators planned to investigate the possible benefits of preemptive administration of atropine, the dose of which is calculated in proportion to the patient's weight, as soon as a 10% decrease in heart rate is detected, in order to balance the sympathetic blockade due to spinal anesthesia in cesarean section operations.

NCT ID: NCT05853744 Recruiting - Anxiety Clinical Trials

Effect of Aromatherapy on Preoperative Anxiety Level

Start date: August 2, 2023
Phase: Phase 4
Study type: Interventional

The aim of the study was to evaluate the efficacy of lavender aromatherapy in reducing pre-operative anxiety in patients undergoing surgical procedures under spinal anesthesia. This was a prospective double blinded randomized controlled trial. After patient's approval, the anxiety level was assessed preoperativetively with Visual Analogue scale-anxiety and APAIS scale. To rule out any lavender sensitivity, all subjects were given a skin patch test. This was accomplished by applying a drop of lavender oil to the back of the hand and covering it with a Tegaderm dressing to prevent inhalation and spread of the oil. After randomisation and allocation, the investigators prooceeded with the intervention preoperatively. In the operating room, the acte under spinal anethesia was performed. Then we collect data postoperatively.

NCT ID: NCT05824338 Not yet recruiting - Anesthesia, Spinal Clinical Trials

Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back Surgery

SASS
Start date: January 1, 2024
Phase: Early Phase 1
Study type: Interventional

The goal of this pilot clinical trial is to test the feasibility of conducting a randomized controlled trial that will examine the use of ropivacaine in the spinal anesthesia for patients undergoing elective 1- or 2-level lower spine surgery. This study aims to: - Determine the rates of eligibility, recruitment, consent, and attrition - Determine the acceptability among patients, surgeons, anesthesiologists, and nurses of doing spine surgery under spinal anesthesia - Gather preliminary data on outcomes relevant to a future dose-finding study Participants will be randomized to one of three treatment groups: - General anesthesia with endotracheal tube - Spinal anesthesia with bupivacaine - Spinal anesthesia with ropivacaine

NCT ID: NCT05685212 Completed - Blood Pressure Clinical Trials

Prediction of Hypotension During Cesarean Delivery Using Positional Change of Hemodynamic Parameters

Start date: April 1, 2023
Phase:
Study type: Observational

This was a prospective observational study between January 2022 and June 2022. The investigators included parturients aged 18 to 45 years, consenting, classified ASA II and III, scheduled for elective or emergency cesarean section (Lucas III-IV). Baseline hemodynamic parameters were measured in 3 different positions: sitting, supine, and left lateral tilt 15°. The investigators defined Δ1 as the change from the sitting position to the supine position ad Δ2 as the change from the left lateral tilt 15° position to the supine position. Our primary endpoint was the incidence of hypotension defined as a decrease of more than 20% from baseline values. The investigators performed univariate and then multivariate analysis.

NCT ID: NCT05654363 Completed - Pain, Postoperative Clinical Trials

Observational Retrospective Study on Spinal Analgesia in Laparoscopic and Laparotomic Hysterectomy

SPIN_GYN
Start date: March 13, 2023
Phase:
Study type: Observational

Perioperative multimodal analgesia, defined by the use of various analgesic medications targeting different drug receptors, provides adequate pain relief with minimal or no opiate consumption. Therefore, it represents one of the cornerstone of Enhanced Recovery After Surgery (ERAS) protocols, as the reduction in opioid use and the associated side effects may eventually reduce length of hospital stay, increase patient satisfaction and minimise the risk of long-term opioid use. Regional and neuraxial anesthesia techniques are key interventions to provide successful analgesia in the context of a multimodal strategy. Intrathecal morphine, for its effectiveness and potential of reducing the need of intravenous postoperative opioids, seems an attractive option in the case of hysterectomy, one of the most common major surgical procedures performed in women, associated with severe postoperative pain even when performed laparoscopically. The aim of our observational retrospective study is therefore to compare the analgesic efficacy and the safety of morphine administered by intrathecal route versus intravenous route during the first 48 hours after performance of laparoscopic/laparotomic hysterectomy.

NCT ID: NCT05651399 Recruiting - Anesthesia, Spinal Clinical Trials

Comparison in Frequency of Hypotension Between Remimazolam and Propofol in Hip Surgery

Start date: December 26, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the incidence of hypotension between remimazolam and propofol for intraoperative sedation in patients undergoing hip surgery with spinal anesthesia.