Clinical Trials Logo

Clinical Trial Summary

A Phase 3, randomized, placebo-controlled, double-masked, parallel study in healthy subjects. It is designed to evaluate the ocular safety of a single topical ocular administration of AG-920 sterile topical ophthalmic solution compared to placebo..


Clinical Trial Description

A Phase 3, randomized, placebo-controlled, double-masked, parallel study in healthy subjects performed in the US. It is designed to evaluate the ocular safety of one dose of AG-920 compared to placebo. I). In this study, subjects who provide informed consent and fulfill all the inclusion criteria and none of the exclusion criteria will be randomized in a 2:1 ratio to receive one dose of AG-920 or identical looking placebo into one (study) eye. A subset of subjects will undergo endothelial cell count (ECC) evaluations. Each dose of AG-920 or placebo will consist of two drops in the study eye. After the completion of dosing, subjects will undergo a series of eye exams that will be documented. Investigational medicinal product (IMP) dosing will be performed by the study staff. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05501860
Study type Interventional
Source American Genomics, LLC
Contact
Status Completed
Phase Phase 3
Start date July 30, 2022
Completion date December 7, 2022

See also
  Status Clinical Trial Phase
Completed NCT03663478 - Continuous TQL Block for Elective Cesarean Section Phase 4
Completed NCT04513652 - A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution Phase 3
Completed NCT05464862 - The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers Phase 4
Completed NCT04690647 - The Efficacy of Suprainguinal Fascia Iliaca Compartment Block for Analgesia After Elective Total Hip Replacement. N/A
Completed NCT03245359 - Pain Management After TKA: Comparison of Short- and Long-term Nerve Blocks N/A
Recruiting NCT06028126 - Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial N/A
Not yet recruiting NCT05815563 - Validation of Peripheral Perfusion Index in Predicting Successful Supraclavicular Brachial Plexus Block in Pediatrics
Completed NCT01418690 - Changes in Tissue Oxygenation Following Regional Anesthesia N/A
Suspended NCT03291691 - Protective Nerve Stimulation in Regional Anesthesia
Not yet recruiting NCT03545516 - Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery Phase 2
Not yet recruiting NCT05038007 - Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades Phase 2
Terminated NCT03672500 - Perineal Local Infiltration Study N/A
Enrolling by invitation NCT06057090 - Do Therapy Dogs Improve Behavior and Reduce Anxiety in Pediatric Dental Patients? N/A
Recruiting NCT05415865 - The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder Phase 3
Recruiting NCT06011005 - Efficacy of Ethyl Chloride Topical Anesthesia Application on the Pain Perception During Intra-oral Injections in Children in Comparison to Benzocaine Gel. N/A
Completed NCT04536311 - Surgical Stabilization of Rib Fractures While Awake or Under Appropriate Sedation by Paravertebral Block N/A
Completed NCT03600454 - The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response N/A
Recruiting NCT03159338 - Platelet-rich Fibrin on Nerve Regeneration After Bilateral Sagittal Split Osteotomy N/A
Completed NCT02966067 - A Split Mouth Trial to Compare Microneedles vs. Standard Needles in Dental Anaesthetic Delivery N/A
Completed NCT03305666 - Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures Phase 4